Associations of mitochondrial genomic variation with successful neurological aging

IF 3.9 3区生物学 Q2 CELL BIOLOGY

Mitochondrion Pub Date : 2024-09-01 DOI:10.1016/j.mito.2024.101948

Nicole Tamvaka , Michael G. Heckman , Patrick W. Johnson , Alexandra I. Soto-Beasley , Ronald L. Walton , Shunsuke Koga , Ryan J. Uitti , Francine Parfitt , Michelle R. Graff-Radford , Zbigniew K. Wszolek , Neill Graff-Radford , Rebecca R. Valentino , Owen A. Ross

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Abstract

Mitochondrial health is an integral factor in aging, with mitochondrial dysfunction known to increase with age and contribute to the development of age-related neurodegenerative disorders. Additionally, the mitochondrial genome (mtDNA) has been shown to acquire potentially damaging somatic variation as part of the aging process, while mtDNA single nucleotide polymorphism (SNPs) have been shown to be both protective and detrimental for various neurodegenerative diseases. Yet, little is known about the involvement of mtDNA variation in longevity and successful neurological aging. In this study, we examined the association of mtDNA SNPs, in the form of mitochondrial haplogroups, with successful neurological aging in 1,405 unrelated neurologically healthy subjects. Although not quite significant after correcting for multiple testing (P < 0.0017 considered as significant), we detected a nominally significant association between the I haplogroup (N = 45, 3.2 %) and a younger age (β: −5.00, P = 0.006), indicating that this haplogroup is observed less frequently in older neurologically healthy individuals and may be associated with decreased survival. Replication of this finding in independent neurologically healthy cohorts will be imperative for shaping our understanding of the biological processes underlying healthy neurological aging.

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线粒体基因组变异与神经系统成功衰老的关系。

线粒体健康是衰老的一个不可或缺的因素，线粒体功能障碍会随着年龄的增长而增加，并导致与年龄相关的神经退行性疾病的发生。此外，线粒体基因组（mtDNA）已被证明在衰老过程中会发生具有潜在破坏性的体细胞变异，而 mtDNA 单核苷酸多态性（SNPs）已被证明对各种神经退行性疾病既有保护作用也有损害作用。然而，人们对 mtDNA 变异参与长寿和神经系统成功衰老的情况知之甚少。在这项研究中，我们以线粒体单倍群的形式研究了 1405 名无亲属关系的神经系统健康受试者的 mtDNA SNPs 与神经系统成功衰老的关系。尽管经多重检验校正后，结果并不十分显著（P

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mitochondrion 生物-细胞生物学

CiteScore

9.40

自引率

4.50%

发文量

审稿时长

13.6 weeks

期刊介绍： Mitochondrion is a definitive, high profile, peer-reviewed international research journal. The scope of Mitochondrion is broad, reporting on basic science of mitochondria from all organisms and from basic research to pathology and clinical aspects of mitochondrial diseases. The journal welcomes original contributions from investigators working in diverse sub-disciplines such as evolution, biophysics, biochemistry, molecular and cell biology, genetics, pharmacology, toxicology, forensic science, programmed cell death, aging, cancer and clinical features of mitochondrial diseases.