Exhaled Volatile Organic Compounds Detection in Pneumonia Screening: A Comprehensive Meta-analysis.

IF 4.6 2区医学 Q1 RESPIRATORY SYSTEM

Lung Pub Date : 2024-10-01 Epub Date: 2024-08-24 DOI:10.1007/s00408-024-00737-8

Juan He, Ran Zhong, Linlu Xue, Yixuan Wang, Yang Chen, Zihui Xiong, Ziya Yang, Sitong Chen, Wenhua Liang, Jianxing He

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引用次数: 0

Abstract

Background: Pneumonia is a common lower respiratory tract infection, and early diagnosis is crucial for timely treatment and improved prognosis. Traditional diagnostic methods for pneumonia, such as chest imaging and microbiological examinations, have certain limitations. Exhaled volatile organic compounds (VOCs) detection, as an emerging non-invasive diagnostic technique, has shown potential application value in pneumonia screening.

Method: A systematic search was conducted on PubMed, Embase, Cochrane Library, and Web of Science, with the retrieval time up to March 2024. The inclusion criteria were diagnostic studies evaluating exhaled VOCs detection for the diagnosis of pneumonia, regardless of the trial design type. A meta-analysis was performed using a bivariate model for sensitivity and specificity.

Results: A total of 14 diagnostic studies were included in this meta-analysis. The pooled results demonstrated that exhaled VOCs detection had a combined sensitivity of 0.94 (95% CI: 0.92-0.95) and a combined specificity of 0.83 (95% CI: 0.81-0.84) in pneumonia screening, with an area under the summary receiver operating characteristic (SROC) curve (AUC) of 0.96. The pooled diagnostic odds ratio (DOR) was 104.37 (95% CI: 27.93-390.03), and the pooled positive and negative likelihood ratios (LR) were 8.98 (95% CI: 3.88-20.80) and 0.11 (95% CI: 0.05-0.22), indicating a high diagnostic performance.

Conclusion: This study highlights the potential of exhaled VOCs detection as an effective, non-invasive screening method for pneumonia, which could facilitate future diagnosis in pneumonia. Further high-quality, large-scale studies are required to confirm the clinical utility of exhaled VOCs detection in pneumonia screening.

Study registration: PROSPERO, Review no. CRD42024520498.

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肺炎筛查中的呼出挥发性有机化合物检测：综合 Meta 分析。

背景：肺炎是一种常见的下呼吸道感染，早期诊断对于及时治疗和改善预后至关重要。传统的肺炎诊断方法，如胸部影像学检查和微生物学检查，都有一定的局限性。呼出的挥发性有机化合物（VOCs）检测作为一种新兴的无创诊断技术，在肺炎筛查中显示出潜在的应用价值：在 PubMed、Embase、Cochrane Library 和 Web of Science 上进行了系统检索，检索时间截至 2024 年 3 月。纳入标准是评估呼出挥发性有机化合物检测对肺炎诊断的诊断性研究，无论试验设计类型如何。采用双变量模型对敏感性和特异性进行了荟萃分析：本次荟萃分析共纳入了 14 项诊断研究。汇总结果显示，在肺炎筛查中，呼出 VOCs 检测的综合灵敏度为 0.94（95% CI：0.92-0.95），综合特异度为 0.83（95% CI：0.81-0.84），汇总接收者操作特征曲线下面积（AUC）为 0.96。汇总诊断几率比（DOR）为 104.37（95% CI：27.93-390.03），汇总阳性和阴性似然比（LR）分别为 8.98（95% CI：3.88-20.80）和 0.11（95% CI：0.05-0.22），显示出较高的诊断性能：本研究强调了呼出挥发性有机化合物检测作为一种有效、无创的肺炎筛查方法的潜力，这将有助于未来的肺炎诊断。研究注册：研究注册：PROSPERO，审查号：CRD42024520498。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lung 医学-呼吸系统

CiteScore

9.10

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Lung publishes original articles, reviews and editorials on all aspects of the healthy and diseased lungs, of the airways, and of breathing. Epidemiological, clinical, pathophysiological, biochemical, and pharmacological studies fall within the scope of the journal. Case reports, short communications and technical notes can be accepted if they are of particular interest.