Feeling of incomplete bladder emptying and angiogenesis-related polymorphism rs3025020 among older community-dwelling individuals

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-08-24 DOI:10.1111/ggi.14970

Yuji Shimizu, Shin-Ya Kawashiri, Yuko Noguchi, Nagisa Sasaki, Seiko Nakamichi, Kazuhiko Arima, Yasuhiro Nagata, Takahiro Maeda

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Abstract

Aim

To clarify the association between genetic factors related to angiogenesis and feeling of incomplete bladder emptying among older community-dwelling individuals.

Method

A cross-sectional study of 1762 (607 men and 1155 women) older Japanese individuals aged 60–79 years with data on rs3025020 was conducted, because vascular endothelial growth factor (VEGF), which contributes to the progression of angiogenesis, has been reported to be positively associated with the minor allele (T) of polymorphism rs3025020.

Results

In the study population, 155 (103 men and 52 women) had feeling of incomplete bladder emptying. With rs3025020 (C/C) as the reference group, rs3025020 (T/T) was associated with a significantly higher odds ratio (OR) for feeling of incomplete bladder emptying. The adjusted ORs and 95% confidence intervals were 3.01(1.53, 5.93) in men and 2.48 (1.09, 5.66) in women, respectively.

Conclusion

VEGF polymorphism rs3025020 was associated with feeling of incomplete bladder emptying among older community-dwelling individuals. Development of angiogenesis could be associated with feeling of incomplete bladder emptying in older individuals. Geriatr Gerontol Int 2024; 24: 1039–1044.

查看原文本刊更多论文

社区老年人的膀胱排空不完全感与血管生成相关多态性 rs3025020。

目的：阐明与血管生成有关的遗传因素与社区老年人膀胱排空不完全感之间的关系：方法：对1762名（男性607名，女性1155名）60-79岁的日本老年人进行了横断面研究，并获得了rs3025020的数据，因为血管内皮生长因子（VEGF）有助于血管生成的进展，有报道称血管内皮生长因子与多态性rs3025020的小等位基因（T）呈正相关：研究人群中有 155 人（男性 103 人，女性 52 人）有膀胱排空不完全的感觉。以 rs3025020 (C/C) 为参照组，rs3025020 (T/T) 与膀胱排空不完全感的几率比（OR）显著较高相关。男性和女性的调整后 ORs 和 95% 置信区间分别为 3.01(1.53, 5.93)和 2.48(1.09, 5.66)：VEGF多态性rs3025020与社区老年人的膀胱排空不完全感有关。血管生成的发展可能与老年人的膀胱排空不完全感有关。Geriatr Gerontol Int 2024; --：-----.

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464