Correlation between choroidal parameters and primary angle-closure suspect in different age groups.

IF 2 Q2 OPHTHALMOLOGY

BMJ Open Ophthalmology Pub Date : 2024-08-22 DOI:10.1136/bmjophth-2024-001772

Mengyang Li, Zhi Li, Fei Xiang, Caixia Li, Ye Zhang, Shuning Li

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Abstract

Objective: To investigate the correlations between choroidal parameters and primary angle-closure suspect (PACS) in different age subgroups.

Methods and analysis: Participants aged 50 years or older in a rural area of Daxing District, Beijing, were recruited. Swept-source optical coherence tomography was used to measure the choroidal parameters. Demographic, ocular biometry parameters and choroidal parameters were compared between the PACS and non-PACS (NPACS) eyes. Logistic analysis was performed to explore the association between the choroidal parameters and PACS.

Results: 192 (26.89%) subjects with PACS and 509 (71.29%) with PACS were analysed. Subjects were divided into two groups: group 1 (50-60 years, n=286) and group 2 (>60 years, n=415). In group 1, the mean subfoveal choroidal thickness of PACS eyes was 341.82±88.23 µm and thicker than NPACS eyes (315.07±83.53 µm, p=0.035). The choroidal volume was greater in PACS eyes (10.61±2.78 mm³) compared with NPACS eyes (9.66±2.49 mm³, p=0.013). In group 2, no significant difference in any choroidal parameters between PACS and NPACS was found. Multivariate regression demonstrated that increased choroidal volume was associated with PACS (OR 1.298, 95% CI 1.117 to 1.510, p<0.001) in group 1.

Conclusions: In the age group of 50-60 years, PACS eyes had greater choroidal thickness and volume than NPACS eyes, and the increased total choroidal volume was a predisposing factor for PACS.

Trial registration number: ChiCTR2000037944.

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不同年龄组的脉络膜参数与原发性闭角怀疑症之间的相关性。

目的研究不同年龄亚组的脉络膜参数与原发性闭角型疑似角膜病（PACS）之间的相关性：方法：招募北京市大兴区农村地区 50 岁及以上的参与者。采用扫源光学相干断层扫描测量脉络膜参数。比较了 PACS 和非 PACS（NPACS）眼睛的人口统计学、眼部生物测量参数和脉络膜参数。对脉络膜参数和 PACS 之间的关系进行了逻辑分析：分析了 192 名（26.89%）患有 PACS 的受试者和 509 名（71.29%）患有 PACS 的受试者。受试者分为两组：第一组（50-60 岁，n=286）和第二组（大于 60 岁，n=415）。在第 1 组中，PACS 眼睛的平均眼底脉络膜厚度为（341.82±88.23）微米，比 NPACS 眼睛更厚（315.07±83.53）微米，P=0.035）。与 NPACS 眼睛（9.66±2.49 mm3，P=0.013）相比，PACS 眼睛的脉络膜体积更大（10.61±2.78 mm3）。在第 2 组中，PACS 和 NPACS 的脉络膜参数均无明显差异。多变量回归显示，脉络膜体积的增加与 PACS 相关（OR 1.298，95% CI 1.117 至 1.510，p 结论：在50-60岁年龄组中，PACS眼的脉络膜厚度和体积均大于NPACS眼，脉络膜总体积的增加是PACS的易感因素：试验注册号：ChiCTR2000037944。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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