Prognostic effect of the pretreatment prognostic nutritional index in cervical, ovarian, and endometrial cancer: a meta-analysis.

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY

BMC Women's Health Pub Date : 2024-08-23 DOI:10.1186/s12905-024-03310-w

Chun Li, Yalei Yin, Zhen Yang, Qing Zhang, Wei Wang, Junqiang Liu

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引用次数: 0

Abstract

Background: The prognostic value of the pretreatment prognostic nutritional index (PNI) for gynaecological malignancies remain unclear. This meta-analysis aimed to explore the predictive significance of the PNI for gynaecological tumours.

Methods: The PubMed, Embase, Web of Science, and Cochrane Library databases were searched up to January 30, 2024, to identify relevant studies. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to assess the associations of the PNI with overall survival (OS), progression-free survival (PFS), and disease-free survival (DFS) in patients with gynaecological tumours. We examined the correlation of the PNI with clinicopathological parameters of patients with gynaecological carcinoma by utilizing pooled odds ratios (ORs) and 95% CIs.

Results: A total of 28 articles involving 9,428 patients were included in the meta-analysis. The results revealed that a low PNI significantly predicted worse OS (HR = 1.60, 95% CI: 1.39-1.84, P < 0.001), PFS (HR = 1.63, 95% CI: 1.20-2.23, P = 0.002), and DFS (HR = 1.73, 95% CI: 1.19-2.52, P = 0.004). In addition, the subgroup analysis confirmed that the PNI had a prognostic effect on OS for all cancer types, but a significant association with PFS was not observed in patients with cervical cancer. A low PNI was significantly associated with FIGO stages III‒IV (OR = 2.30, 95% CI: 1.89‒2.80, P < 0.001) and LN metastasis (OR = 2.76, 95% CI: 2. 05‒3.73, P < 0.001).

Conclusion: The PNI may be noninvasive and promising biomarker for predicting the prognosis of patients with gynaecological tumours.

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宫颈癌、卵巢癌和子宫内膜癌预后营养指数的预后效果：一项荟萃分析。

背景：妇科恶性肿瘤预后营养指数（PNI）的预后价值尚不明确。本荟萃分析旨在探讨 PNI 对妇科肿瘤的预测意义：方法：检索了截至 2024 年 1 月 30 日的 PubMed、Embase、Web of Science 和 Cochrane Library 数据库，以确定相关研究。通过计算危险比（HRs）和95%置信区间（CIs）来评估PNI与妇科肿瘤患者总生存期（OS）、无进展生存期（PFS）和无病生存期（DFS）的相关性。我们利用汇总的几率比（ORs）和 95% CIs 检验了 PNI 与妇科肿瘤患者临床病理参数的相关性：荟萃分析共纳入28篇文章，涉及9428名患者。结果显示，低 PNI 显著预示着较差的 OS（HR = 1.60，95% CI：1.39-1.84，P 结论：PNI 可能是一种非肿瘤性指标：PNI可能是预测妇科肿瘤患者预后的非侵入性和有前途的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Women's Health OBSTETRICS & GYNECOLOGY-

CiteScore

3.40

自引率

4.00%

发文量

444

审稿时长

>12 weeks

期刊介绍： BMC Women''s Health is an open access, peer-reviewed journal that considers articles on all aspects of the health and wellbeing of adolescent girls and women, with a particular focus on the physical, mental, and emotional health of women in developed and developing nations. The journal welcomes submissions on women''s public health issues, health behaviours, breast cancer, gynecological diseases, mental health and health promotion.