Short inter-pregnancy interval and birthweight: a reappraisal based on a follow-up study of all women in Norway with two singleton deliveries during 1970–2019

IF 7.7 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Anne Eskild, Irene Skau, Camilla Haavaldsen, Ola Didrik Saugstad, Jostein Grytten
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Abstract

We studied mean changes in birthweight from the first to the second delivery according to length of the inter-pregnancy interval. We also studied recurrence risk of low birthweight, preterm birth and perinatal death. We followed all women in Norway from their first to their second singleton delivery at gestational week 22 or beyond during the years 1970–2019, a total of 654 100 women. Data were obtained from the Medical Birth Registry of Norway. Mean birthweight increased from the first to the second delivery, and the increase was highest in pregnancies conceived < 6 months after the first delivery; adjusted mean birthweight increase 227 g (g) (95% CI; 219–236 g), 90 g higher than in pregnancies conceived 6–11 months after the first delivery (137 g (95% CI; 130–144 g)). After exclusion of women with a first stillbirth, the mean increase in birthweight at inter-pregnancy interval < 6 months was attenuated (152 g, 95% CI; 143–160 g), but remained higher than at longer inter-pregnancy intervals. This finding was particularly prominent in women > 35 years (218 g, 95% CI; 139 –298 g). In women with a first live born infant weighing < 2500 g, mean birthweight increased by around 1000 g to the second delivery, and the increase was most prominent at < 6 months inter-pregnancy interval. We found increased recurrence risk of preterm birth at inter-pregnancy interval < 6 months, but no increased recurrence risk of low birthweight, small for gestational age infant or perinatal death. In conclusion, we found the highest mean increase in birthweight when the inter-pregnancy interval was short. Our results do not generally discourage short pregnancy intervals.

Abstract Image

孕间隔短与出生体重:基于对1970-2019年期间挪威所有单胎分娩妇女的跟踪研究的再评估
我们根据两次妊娠间隔时间的长短,研究了从第一次分娩到第二次分娩的出生体重平均变化情况。我们还研究了低出生体重、早产和围产期死亡的复发风险。在1970-2019年期间,我们对挪威所有孕周在22周或22周以上的妇女从第一次分娩到第二次分娩的单胎分娩情况进行了跟踪调查,共计654 100名妇女。数据来自挪威出生医学登记处。从第一次分娩到第二次分娩,平均出生体重有所增加,第一次分娩后6个月受孕的孕妇出生体重增幅最大;调整后的平均出生体重增加了227克(95% CI;219-236克),比第一次分娩后6-11个月受孕的孕妇高出90克(137克(95% CI;130-144克))。在剔除第一胎死产的妇女后,怀孕间隔为 6 个月的妇女出生体重的平均增幅有所减弱(152 克,95% CI;143-160 克),但仍高于怀孕间隔更长的妇女。这一结果在 35 岁妇女中尤为突出(218 克,95% CI;139 -298 克)。在第一胎活产婴儿体重为 2500 克的妇女中,平均出生体重在第二次分娩时增加了约 1000 克,在两次妊娠间隔为 6 个月时增加最为明显。我们发现,孕间隔 6 个月时早产的复发风险增加,但低出生体重儿、小胎龄儿或围产期死亡的复发风险没有增加。总之,我们发现怀孕间隔短时,出生体重的平均增幅最大。一般来说,我们的结果并不鼓励缩短怀孕间隔。
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来源期刊
European Journal of Epidemiology
European Journal of Epidemiology 医学-公共卫生、环境卫生与职业卫生
CiteScore
21.40
自引率
1.50%
发文量
109
审稿时长
6-12 weeks
期刊介绍: The European Journal of Epidemiology, established in 1985, is a peer-reviewed publication that provides a platform for discussions on epidemiology in its broadest sense. It covers various aspects of epidemiologic research and statistical methods. The journal facilitates communication between researchers, educators, and practitioners in epidemiology, including those in clinical and community medicine. Contributions from diverse fields such as public health, preventive medicine, clinical medicine, health economics, and computational biology and data science, in relation to health and disease, are encouraged. While accepting submissions from all over the world, the journal particularly emphasizes European topics relevant to epidemiology. The published articles consist of empirical research findings, developments in methodology, and opinion pieces.
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