High-intensity intermittent exercise increases serum levels of chitinase 3-like protein-1 and matrix metalloproteinase-9 in persons with multiple sclerosis

IF 2.9 4区医学 Q3 IMMUNOLOGY

Journal of neuroimmunology Pub Date : 2024-08-20 DOI:10.1016/j.jneuroim.2024.578434

Furkan Bilek , Zubeyde Ercan , Gulnihal Deniz , Sinem Ozgul , Caner Feyzi Demir

引用次数: 0

Abstract

The study aimed to evaluate the effect of high-intensity intermittent exercise (HIIE) on serum levels of MMP-9 and CHI3L1 in multiple sclerosis. Study group received HIIE twice a week for 12 weeks, while control group received no treatment. In intra-group comparison, study group showed a significant increase in MMP-9 and CHI3L1 levels, while control group showed no significant difference. In intergroup comparison, a significant difference was found only in CHI3L1 levels after treatment. The increase in MMP-9 and CH3L-1 concentrations in study group suggests that these biomarkers may play a role in regulating specific skeletal muscle adaptations due to HIIE.

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高强度间歇运动可提高多发性硬化症患者血清中几丁质酶 3 样蛋白-1 和基质金属蛋白酶-9 的水平

该研究旨在评估高强度间歇运动（HIIE）对多发性硬化症患者血清中MMP-9和CHI3L1水平的影响。研究组每周接受两次高强度间歇运动，为期12周，对照组不接受任何治疗。在组内比较中，研究组的 MMP-9 和 CHI3L1 水平显著升高，而对照组无显著差异。在组间比较中，发现只有 CHI3L1 水平在治疗后有显著差异。研究组中 MMP-9 和 CH3L-1 浓度的增加表明，这些生物标志物可能在 HIIE 引起的特定骨骼肌适应性调节中发挥作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of neuroimmunology 医学-免疫学

CiteScore

6.10

自引率

3.00%

发文量

154

审稿时长

37 days

期刊介绍： The Journal of Neuroimmunology affords a forum for the publication of works applying immunologic methodology to the furtherance of the neurological sciences. Studies on all branches of the neurosciences, particularly fundamental and applied neurobiology, neurology, neuropathology, neurochemistry, neurovirology, neuroendocrinology, neuromuscular research, neuropharmacology and psychology, which involve either immunologic methodology (e.g. immunocytochemistry) or fundamental immunology (e.g. antibody and lymphocyte assays), are considered for publication.