{"title":"An injectable hyaluronic acid-Polydeoxyribonucleotides (HA-PDRN) crosslinked hydrogel as a dermal filler","authors":"Guo jiahong , Fang wei , Wang feifei","doi":"10.1016/j.eurpolymj.2024.113395","DOIUrl":null,"url":null,"abstract":"<div><p>Injectable hydrogels, commonly utilized as dermal fillers, show great potential for increasing tissue volume and correcting wrinkles. HA (hyaluronic acid), extensively used in dermal fillers, requires considerable modifications to meet commercial demands for effectiveness and functionality. PDRN (polydeoxyribonucleotides), DNA extracted from salmon sperm cells, offer several therapeutic benefits, including anti-inflammatory and collagen stimulation. This work presents a new crosslinked hydrogel based on HA and PDRN. HA-PDRN crosslinked hydrogels were fabricated via covalent interactions between the carboxyl groups of HA and amino groups of PDRN, resulting in desirable properties such as viscoelasticity, appearance, hydration, degradation, injectability, and biocompatibility. In vivo studies on mice revealed that these hydrogels maintain volume for over 24 weeks, with reduced inflammation and enhanced collagen synthesis, as well as exhibiting durability, safety, and supportability.</p></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"219 ","pages":"Article 113395"},"PeriodicalIF":5.8000,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Polymer Journal","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0014305724006566","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
引用次数: 0
Abstract
Injectable hydrogels, commonly utilized as dermal fillers, show great potential for increasing tissue volume and correcting wrinkles. HA (hyaluronic acid), extensively used in dermal fillers, requires considerable modifications to meet commercial demands for effectiveness and functionality. PDRN (polydeoxyribonucleotides), DNA extracted from salmon sperm cells, offer several therapeutic benefits, including anti-inflammatory and collagen stimulation. This work presents a new crosslinked hydrogel based on HA and PDRN. HA-PDRN crosslinked hydrogels were fabricated via covalent interactions between the carboxyl groups of HA and amino groups of PDRN, resulting in desirable properties such as viscoelasticity, appearance, hydration, degradation, injectability, and biocompatibility. In vivo studies on mice revealed that these hydrogels maintain volume for over 24 weeks, with reduced inflammation and enhanced collagen synthesis, as well as exhibiting durability, safety, and supportability.
期刊介绍：
European Polymer Journal is dedicated to publishing work on fundamental and applied polymer chemistry and macromolecular materials. The journal covers all aspects of polymer synthesis, including polymerization mechanisms and chemical functional transformations, with a focus on novel polymers and the relationships between molecular structure and polymer properties. In addition, we welcome submissions on bio-based or renewable polymers, stimuli-responsive systems and polymer bio-hybrids. European Polymer Journal also publishes research on the biomedical application of polymers, including drug delivery and regenerative medicine. The main scope is covered but not limited to the following core research areas:
Polymer synthesis and functionalization
• Novel synthetic routes for polymerization, functional modification, controlled/living polymerization and precision polymers.
Stimuli-responsive polymers
• Including shape memory and self-healing polymers.
Supramolecular polymers and self-assembly
• Molecular recognition and higher order polymer structures.
Renewable and sustainable polymers
• Bio-based, biodegradable and anti-microbial polymers and polymeric bio-nanocomposites.
Polymers at interfaces and surfaces
• Chemistry and engineering of surfaces with biological relevance, including patterning, antifouling polymers and polymers for membrane applications.
Biomedical applications and nanomedicine
• Polymers for regenerative medicine, drug delivery molecular release and gene therapy
The scope of European Polymer Journal no longer includes Polymer Physics.
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