Amugulang virus, a novel hantavirus harboured by small rodents in Hulunbuir, China.

IF 8.4 2区医学 Q1 IMMUNOLOGY

Emerging Microbes & Infections Pub Date : 2024-12-01 Epub Date: 2024-09-05 DOI:10.1080/22221751.2024.2396893

Xiaohu Han, Lianhong Zhang, Mingxuan Zhang, Qing Xin, Yongxiang Zhao, Ya Wen, Hua Deng, Jinguo Zhu, Qin Dai, Mei Han, Tianyu Yang, Saiji Lahu, Feng Jiang, Zeliang Chen

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Abstract

The Hulunbuir region, known for its diverse terrain and rich wildlife, is a hotspot for various natural epidemic diseases. Between 2021 and 2023, we collected 885 wild rodent samples from this area, representing three families, seven genera, and eleven species. Metagenomic analysis identified three complete nucleic acid sequences from the S, M, and L segments of the Hantaviridae family, which were closely related to the Khabarovsk virus. The nucleotide coding sequences for S, M, and L (1392 nt, 3465 nt, and 6491 nt, respectively) exhibited similarities of 82.34%, 81.68%, and 81.94% to known sequences, respectively, while protein-level analysis indicated higher similarities of 94.92%, 94.41%, and 95.87%, respectively. Phylogenetic analysis placed these sequences within the same clade as the Khabarovsk, Puumala, Muju, Hokkaido, Topografov, and Tatenalense viruses, all of which are known to cause febrile diseases in humans. Immunofluorescence detection of nucleic acid-positive rodent kidney samples using sera from patients with hemorrhagic fever and renal syndrome confirmed the presence of viral particles. Based on these findings, we propose that this virus represents a new member of the Hantaviridae family, tentatively named the Amugulang virus, after its primary distribution area.

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中国呼伦贝尔小型啮齿动物携带的新型汉坦病毒--阿姆古朗病毒。

呼伦贝尔地区以其多样的地形和丰富的野生动物而闻名，是各种自然流行病的热点地区。2021 年至 2023 年期间，我们从该地区采集了 885 份野生啮齿动物样本，代表了 3 个科、7 个属和 11 个种。元基因组分析确定了汉坦病毒科S、M和L段的三个完整核酸序列，它们与哈巴罗夫斯克病毒密切相关。S、M和L的核苷酸编码序列（分别为1392 nt、3465 nt和6491 nt）与已知序列的相似度分别为82.34%、81.68%和81.94%，而蛋白质水平分析表明其相似度更高，分别为94.92%、94.41%和95.87%。系统发育分析将这些序列与哈巴罗夫斯克、普马拉、穆朱、北海道、托波格拉弗夫和塔特纳兰斯病毒归入同一支系，所有这些病毒都可导致人类发热性疾病。利用出血热和肾综合征患者的血清对核酸阳性的啮齿动物肾脏样本进行免疫荧光检测，证实了病毒颗粒的存在。基于这些发现，我们认为该病毒是汉坦病毒科的一个新成员，并根据其主要分布地区将其暂时命名为阿姆古朗病毒。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Emerging Microbes & Infections IMMUNOLOGY-MICROBIOLOGY

CiteScore

26.20

自引率

2.30%

发文量

276

审稿时长

20 weeks

期刊介绍： Emerging Microbes & Infections is a peer-reviewed, open-access journal dedicated to publishing research at the intersection of emerging immunology and microbiology viruses. The journal's mission is to share information on microbes and infections, particularly those gaining significance in both biological and clinical realms due to increased pathogenic frequency. Emerging Microbes & Infections is committed to bridging the scientific gap between developed and developing countries. This journal addresses topics of critical biological and clinical importance, including but not limited to: - Epidemic surveillance - Clinical manifestations - Diagnosis and management - Cellular and molecular pathogenesis - Innate and acquired immune responses between emerging microbes and their hosts - Drug discovery - Vaccine development research Emerging Microbes & Infections invites submissions of original research articles, review articles, letters, and commentaries, fostering a platform for the dissemination of impactful research in the field.