Steatosis, inflammation, fibroprogression, and cirrhosis in remnant liver post-liver donation

IF 1.7 Q3 GASTROENTEROLOGY & HEPATOLOGY
JGH Open Pub Date : 2024-08-23 DOI:10.1002/jgh3.70015
Jeby Jacob, Amal Joseph, Harikumar R Nair, Geevarghese Prajob Prasad, Vijosh V Kumar, Lekshmi Thattamuriyil Padmakumari
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Abstract

Background and Aim

This is a cross-sectional observational study conducted on living liver donors focusing on “long-term remnant liver health” specifically looking at steatosis, inflammation, and fibrosis using multiparametric ultra sonological evaluation and noninvasive blood tests.

Methods

Multiparametric ultrasound evaluation included assessment of shear wave elastography (fibrosis), sound speed plane wave ultrasound, attenuation plane wave ultrasound (steatosis), and viscosity plane wave ultrasound (inflammation). Blood test based APRI and FIB-4 were calculated. Liver biopsy was performed if noninvasive evaluation pointed toward clinically relevant fibro progression (F4).

Results

Out of 36 donors, significant fibrosis (>F2) was found in 11 donors (30.5%), seven donors (19.4%) had severe fibrosis (>F3), and two donors had shear wave elastography values suggestive of cirrhosis(F4). Of these two, one donor was extensively evaluated and was found to have biopsy proven cirrhosis with endoscopic evidence of portal hypertension. The prevalence of fatty liver disease in our study group was 50%.

Conclusion

We report the first liver donor cohort with fibroprogression and cirrhosis occurring in the remnant liver. Our donor cohort with a significant proportion having steatosis and fibroprogression underscores the importance of regular follow-up of liver donors and evaluation of remnant liver.

Abstract Image

肝脏捐献后残余肝脏的脂肪变性、炎症、纤维增生和肝硬化
背景和目的 这是一项针对活体肝脏捐献者的横断面观察性研究,重点关注 "长期残留肝脏健康",特别是使用多参数超声评估和无创血液检测来观察脂肪变性、炎症和纤维化。 方法 多参数超声评估包括剪切波弹性成像评估(纤维化)、声速平面波超声评估、衰减平面波超声评估(脂肪变性)和粘度平面波超声评估(炎症)。计算基于血液检测的 APRI 和 FIB-4。如果无创评估显示临床相关的纤维化进展(F4),则进行肝活检。 结果 在 36 名供体中,11 名供体(30.5%)出现明显纤维化(F2),7 名供体(19.4%)出现严重纤维化(F3),两名供体的剪切波弹性成像值提示肝硬化(F4)。在这两名捐献者中,一名捐献者接受了广泛的评估,活检证实其患有肝硬化,内镜检查显示其患有门静脉高压症。在我们的研究小组中,脂肪肝的发病率为 50%。 结论 我们报告了第一例残肝纤维化和肝硬化的肝脏捐献者。我们的肝脏捐献者群体中有相当一部分人患有脂肪变性和肝纤维化,这凸显了定期随访肝脏捐献者和评估残余肝脏的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
JGH Open
JGH Open GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
3.40
自引率
0.00%
发文量
143
审稿时长
7 weeks
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