Novel and reappraised wide-band EEG findings in migraineurs: Its correlation with several clinical variables

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2024-08-02 DOI:10.1016/j.clinph.2024.07.020

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引用次数: 0

Abstract

Objective

Cortical spreading depolarization is one possible pathogenesis of migraine, of which slow neurophysiological change is barely recorded in conventional EEG settings. Using wide-band EEG conditions, we reappraised the features of EEG in migraineurs, including subdelta-band EEG changes.

Methods

This retrospective study included 144 patients with migraine. We delineated EEG of focal delta slow (FDS) (1–4 Hz) by time constant (TC) 0.3 s and focal subdelta slow (FSDS) (< 1 Hz) by TC 2 s. Relationships between clinical variables and EEG findings were evaluated.

Results

Of 144 patients, 39 had aura and 105 did not. FSDS and FDS were observed in 38 and 58 patients, respectively. No EEG was recorded during the aura. In multivariate analysis with the phase of migraine, family history, age, and percentage of sleep during EEG recording, the phase of migraine was related to the occurrence of FSDS (postdrome vs interictal, prodrome, and headache respectively (OR = 49.00 [95% CI = 3.89–616.66], 46.28 [2.99–715.78], 32.79 [2.23–481.96], p = 0.0026, 0.0061, 0.011). FDS was clinically unremarkable for differential evaluation.

Conclusions

Wide-band EEG abnormality in migraineurs, i.e., FSDS, can be affected by migraine phase.

Significance

Wide-band EEG finding could be a biomarker related to clinical variables in migraines.

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偏头痛患者新发现并重新评估的宽波段脑电图：与多个临床变量的相关性

目的皮层扩散性去极化是偏头痛可能的发病机制之一，在传统的脑电图设置中几乎记录不到这种缓慢的神经生理变化。利用宽波段脑电图条件，我们重新评估了偏头痛患者的脑电图特征，包括δ下波段脑电图变化。我们用时间常数（TC）0.3 秒和时间常数（TC）2 秒划分了局灶δ慢（FDS）（1-4 Hz）和局灶δ下慢（FSDS）（< 1 Hz）的脑电图。分别有 38 名和 58 名患者出现 FSDS 和 FDS。在先兆期间没有记录到脑电图。在与偏头痛的阶段、家族史、年龄和脑电图记录期间的睡眠百分比进行的多变量分析中，偏头痛的阶段与FSDS的发生有关（分别为发作后与发作间期、前驱期和头痛（OR = 49.00 [95% CI = 3.89-616.66], 46.28 [2.99-715.78], 32.79 [2.23-481.96], p = 0.0026, 0.0061, 0.011）。结论偏头痛患者的宽波段脑电图异常（即 FSDS）可能受偏头痛阶段的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.