Transgenerational effects of the levonorgestrel-based birth control pill in zebrafish offspring

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2024-08-22 DOI:10.1016/j.etap.2024.104540

Milena Fortuna , Amanda Carolina Cole Varella , Lisiane Siqueira , Suelen Mendonça Soares , Natália Freddo , Jéssica Nardi , Ísis Piasson Barletto , Milena Zanoello Bertuol , Leonardo José Gil Barcellos

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引用次数: 0

Abstract

The consumption of hormone-derived medicines, such as levonorgestrel (LNG), is increasing worldwide, and its discharge into the environment reaches non-target organisms. In our previous study, we exposed the parental generation of zebrafish to environmentally relevant concentrations of LNG during the developmental phase. Subsequently, they had grown in a tank with clean water until adulthood. Now, we allowed this parental generation to reproduce to obtain F1 progeny unexposed to LGN, in order to analyze the transgenerational effects of parental LNG exposure on the survival and hatching of unexposed F1 embryos and the stress and behavior of F1 larvae. Here, we found decreased survival rates with higher LNG concentrations, providing a transgenerational effect. This highlights the environmental impact of exposure to LNG, causing damage at the individual and population level and affecting the next generation at the beginning of development, impacting qualities in the survival of the species.

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左炔诺孕酮避孕药对斑马鱼后代的代际影响

左炔诺孕酮（LNG）等激素类药物的消费量在全球范围内不断增加，其排放到环境中会影响到非目标生物。在我们之前的研究中，我们在斑马鱼的发育阶段将其亲代暴露于环境相关浓度的 LNG 中。随后，斑马鱼在干净的水箱中生长，直至成年。现在，我们让这一代亲本进行繁殖，以获得未暴露于 LGN 的 F1 后代，从而分析亲本 LNG 暴露对未暴露的 F1 胚胎的存活和孵化以及 F1 幼体的应激和行为的跨代影响。在这里，我们发现 LNG 浓度越高，存活率越低，从而产生了跨代效应。这凸显了接触液化天然气对环境的影响，在个体和种群层面造成损害，并在发育初期影响下一代，从而影响物种的生存质量。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.