Ten-Year Follow-Up of Fellow Eyes in Patients with Unilateral Naïve Exudative AMD.

IF 2.3 2区医学 Q2 OPHTHALMOLOGY

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2024-08-14 DOI:10.1097/IAE.0000000000004251

Francesco Pozzo Giuffrida, Marco Nassisi, Lorenzo de Sanctis, Paolo Milella, Alessia Malerba, Chiara Mapelli, Laura Dell'Arti, Marco Casaluci, Francesco Romano, Alessandro Invernizzi, Giovanni Staurenghi, Francesco Viola

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引用次数: 0

Abstract

Purpose: To determine the 10-year morphological outcomes and identify potential risk factors for exudative AMD in the fellow eyes (FE) in patients with naïve exudative AMD.

Methods: Data from 100 patients were retrospectively reviewed. Baseline macular neovascularization (MNV) type in the exudative AMD eye and presence of drusen, intraretinal hyperreflective foci (iHRF), non-foveal incomplete atrophy (iRORA), central retinal thickness and subfoveal choroidal thickness in the FEs were analyzed as biomarkers for progression in the second eye.

Results: 54 patients developed exudative AMD in the FE at the end of the follow-up. Subjects with type 2 and 3 MNV in the exudative AMD eye had a higher risk of exudative AMD in the FE (HR=3.365; p=0.039 and HR=3.801; p=0.037). FEs with drusen (large HR=6.938, p=0.001; cuticular HR=6.937, p<0.0001; subretinal drusenoid deposits HR=13.678, p<0.0001) and iHRF (HR=1.853, p=0.041) were also at higher risk. Seven patients were legally blind by the end of the follow-up.

Conclusions: The rate of exudative AMD in the FE was 54% 10 years after the diagnosis in the exudative eye. The FE of patients with type 2 and 3 MNV was at high risk for early progression. Drusen and iHRF were also significant risk factors for MNV development.

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单侧新发渗出性黄斑变性患者同侧眼的十年随访。

目的：确定新发渗出性AMD患者10年的形态学结果，并识别同眼（FE）渗出性AMD的潜在风险因素：方法：回顾性分析 100 例患者的数据。方法：回顾性分析 100 例患者的数据，分析渗出性 AMD 同眼的基线黄斑新生血管（MNV）类型，以及同眼是否存在色素沉着、视网膜内高反射灶（iHRF）、非眼窝不完全萎缩（iRORA）、视网膜中央厚度和眼底脉络膜厚度，作为第二只眼病情发展的生物标志物：结果：54名患者在随访结束时，FE出现了渗出性AMD。渗出性AMD眼球中存在2型和3型MNV的受试者在FE中发生渗出性AMD的风险较高（HR=3.365；P=0.039和HR=3.801；P=0.037）。有色素沉着的 FE（大块 HR=6.938，p=0.001；切面 HR=6.937，p结论：渗出性视网膜黄斑变性眼在确诊 10 年后的渗出性视网膜黄斑变性率为 54%。2型和3型MNV患者的FE有早期恶化的高风险。日晕和iHRF也是MNV发展的重要风险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Retina-The Journal of Retinal and Vitreous Diseases 医学-眼科学

CiteScore

5.70

自引率

9.10%

发文量

554

审稿时长

3-6 weeks

期刊介绍： RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice. In addition to regular reports from clinical and basic science investigators, RETINA® publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards. Issues are abundantly illustrated in vivid full color. Published 12 times per year, RETINA® is truly a “must have” publication for anyone connected to this field.