Interleukin-6 in COVID-19 Severity Stratification.

Q3 Medicine
Tanaffos Pub Date : 2023-04-01
Fernando Pereira da Silva, Maria Filomena Luís, Filipa Jesus, Joana Ribeiro, Élin Almeida, Sara Braga, Luís Ferreira
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Abstract

Background: The increase in the number of patients with COVID-19 on a global scale made the early recognition of severe forms of the disease essential. Considering that IL-6 acts as a pro-inflammatory mediator, mediating acute phase responses, the objective of this study was to assess its value in the early severity stratification of SARS-CoV2 infection.

Materials and methods: It was a prospective study included IL-6 measurement in patients with SARS-CoV2 infection upon admission to the emergency department. Two groups were considered (Group I: patients without hospitalization criteria; Group II: patients with hospitalization criteria). Analyzed variables were serum levels of IL-6, C-reactive protein, ferritin, d-dimers, sociodemographics, ventilator support, ICU admission, mortality, dates of diagnosis, hospitalization, and discharge. For the statistical analyses, Mann-Whitney test, Pearson's chi-square test, area under the receiver operating characteristic curve, Youden index, and Spearman correlation were applied.

Results: A total number of 117 patients were included. Mean age was significantly higher for group II (72,35±15,39 years; p<0,001). No statistically significant difference was seen between the groups regarding gender (p=0,111). The IL-6 values showed an excellent power of discrimination for the need for hospitalization (AUC=0,888; p<0,001) and the need for ICU admission (AUC=0,897; p=7.9 × 10-5). Also, its cut-off value of 12,4pg/mL for the need for hospitalization and 42,95 pg/mL for the need for ICU admission was determined. Positive correlation was seen between IL-6 value and length of stay [r(35)=0,380; p=0,020]. Three deaths were observed among patients with hospitalization criteria (8,1%).

Conclusion: The value of IL-6 at admission seems to independently influence the probability of hospitalization (general ward or ICU) and its duration.

COVID-19 严重程度分级中的白细胞介素-6。
背景:全球范围内 COVID-19 患者人数的增加使得早期识别严重形式的疾病变得至关重要。考虑到 IL-6 是一种促炎介质,介导急性期反应,本研究旨在评估其在 SARS-CoV2 感染早期严重程度分层中的价值:这是一项前瞻性研究,包括对急诊科收治的 SARS-CoV2 感染患者进行 IL-6 测量。研究分为两组(第一组:未达到住院标准的患者;第二组:达到住院标准的患者)。分析变量包括血清 IL-6 水平、C 反应蛋白、铁蛋白、d-二聚体、社会人口统计学、呼吸机支持、入住重症监护室、死亡率、诊断日期、住院日期和出院日期。统计分析采用了曼-惠特尼检验、皮尔逊卡方检验、受体操作特征曲线下面积、尤登指数和斯皮尔曼相关性:结果:共纳入 117 名患者。第二组患者的平均年龄明显更高(72,35±15,39 岁;p):入院时的 IL-6 值似乎会独立影响住院(普通病房或重症监护室)的概率及其持续时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Tanaffos
Tanaffos Medicine-Critical Care and Intensive Care Medicine
CiteScore
1.10
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0.00%
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