Status of Inflammatory and Coagulation Factors in COVID-19 and Its Relation with the Disease Severity.

Q3 Medicine
Tanaffos Pub Date : 2023-04-01
Atoosa Gharib, Zahra Nematollahi, Behrang Kazeminejad, Ghazal Najafi, Hadi Pashapour, Abdolreza Javadi, Tahmineh Mollasharifi
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Abstract

Background: The role of activation of inflammatory processes in the exacerbation of COVID-19 disease has been fully confirmed. In addition, the occurrence of thromboembolic events in patients with COVID-19 is expected even long after recovery from the disease. However, which factors are essentially prognostic for this disease is still not theoretically agreed upon. What we did in the present study was to evaluate the prognostic role of some inflammatory and coagulation factors in predicting the severity of COVID-19 disease. In this study, the need for ICU admission was considered as a symbol of disease severity.

Materials and methods: Forty-six cases were studied in this cross-sectional study. Patients over 18 years of age with a definitive diagnosis of COVID-19 were assessed in terms of coagulation profiles and inflammatory and cytokine markers. Regarding laboratory data, serum levels of D-dimer, protein S, protein C, FDP, and fibrinogen were measured using an automated coagulation analyzer, and serum levels of interleukin-6 were measured using the ELISA technique.

Results: In total, 21 patients (45.7%) were admitted to the ICU due to the severity of the disease. In comparing inflammatory and coagulation factors between the two groups of patients, with and without ICU admission, a significant difference was revealed between fibrinogen (P=0.023), D-dimer (P=0.047), protein C (P=0.001), and protein S level (P=0.014). The decrease in protein C level had the highest value for predicting the severity of the disease and therefore the need for ICU admission.

Conclusion: Among various inflammatory and coagulation factors, the role of fibrinogen, D-dimer, protein C, and protein S in predicting the severe form of COVID-19 and the patient's need for ICU admission was confirmed.

COVID-19 中炎症和凝血因子的状况及其与疾病严重程度的关系
背景:炎症过程的激活在 COVID-19 疾病恶化中的作用已得到充分证实。此外,COVID-19 患者即使在疾病痊愈后很长时间内仍会发生血栓栓塞事件。然而,哪些因素对这种疾病的预后有本质的影响,理论上仍未达成一致。在本研究中,我们评估了一些炎症和凝血因子在预测 COVID-19 疾病严重程度方面的预后作用。在本研究中,入住重症监护室的必要性被视为疾病严重程度的象征:这项横断面研究共收集了 46 个病例。对确诊为 COVID-19 的 18 岁以上患者进行了凝血谱、炎症和细胞因子标志物评估。在实验室数据方面,使用自动凝血分析仪测量了血清中 D-二聚体、蛋白 S、蛋白 C、FDP 和纤维蛋白原的水平,并使用 ELISA 技术测量了血清中白细胞介素-6 的水平:共有 21 名患者(45.7%)因病情严重而住进了重症监护室。在比较入住和未入住 ICU 两组患者的炎症和凝血因子时,发现纤维蛋白原(P=0.023)、D-二聚体(P=0.047)、蛋白 C(P=0.001)和蛋白 S 水平(P=0.014)之间存在显著差异。蛋白 C 水平的下降对预测疾病的严重程度以及是否需要入住重症监护室的价值最高:结论:在各种炎症因子和凝血因子中,纤维蛋白原、D-二聚体、蛋白 C 和蛋白 S 在预测 COVID-19 严重程度和患者是否需要入住 ICU 方面的作用得到了证实。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Tanaffos
Tanaffos Medicine-Critical Care and Intensive Care Medicine
CiteScore
1.10
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