Relationship between Underlying Diseases with Morbidity and Mortality in Patients with COVID-19.

Q3 Medicine
Tanaffos Pub Date : 2023-04-01
Navid Shafigh, Morteza Hasheminik, Batoul Khoundabi, Hamidreza Jamaati, Payam Tabarsi, Majid Marjani, Elnaz Shafigh, Majid Malekmohammad, Navid Nooraei, Seyed Mohammad Reza Hashemian
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Abstract

Background: This study aims to investigate the clinical and demographic features of underlying medical conditions and the potential relationship between underlying diseases and the increased rate of morbidity and mortality due to COVID-19.

Materials and methods: This study was conducted on 350 COVID-19 patients hospitalized at the Masih Daneshvari Hospital from February-July 2021. All participants had confirmed COVID-19 diagnosis based on symptoms and/or positive PCR test or chest X-ray results. Data was collected from medical records on demographics, disease severity, symptoms, underlying conditions like diabetes, hypertension, coronary heart disease, obesity, renal disease/transplantation, and outcomes like hospital stay, ICU admission, and mortality. Relationships between age, underlying diseases, and mortality were analyzed using chi-square and Fisher's exact tests."

Results: A total of 350 patients diagnosed with COVID-19 were included in the study, with an average estimated age of (60.8±15.4). The age group of 56 and above had the highest morbidity rate, which accounted for 50% of the total participants. Among the COVID-19 patients, diabetes was the most common underlying medical condition, accounting for 31.4% of the cases. High blood pressure was present in 27.1% of the patients, and 17.1% of the total participants had coronary heart disease (CHD). Additionally, 10.9% of the participants were overweight, and 30 of them had previously experienced kidney failure or transplantation. Moreover, the study found that 40% of patients with diabetes died, while the mortality rate was 38.3% in patients with CHD and 47.4% in overweight participants. High blood pressure patients had a mortality rate of 43.2%, and patients with renal failure or kidney transplantation had a significantly increased risk of mortality at 83.3%. The research also revealed a significant and direct relationship between mortality rate, age group, and underlying disease among the patients (P<0.05).

Conclusion: The findings of the present study hold significant implications for preventive interventions and policy adoption, particularly in relation to the use of calendar age as the key criterion for risk evaluation. These results underscore the need for a more precise and focused approach to prioritizing patients with identified risk factors.

COVID-19 患者的基础疾病与发病率和死亡率之间的关系。
研究背景本研究旨在调查基础疾病的临床和人口特征,以及基础疾病与 COVID-19 导致的发病率和死亡率增加之间的潜在关系:研究对象为 2021 年 2 月至 7 月期间在马西赫-达内什瓦里医院住院的 350 名 COVID-19 患者。所有参与者均根据症状和/或阳性 PCR 检测或胸部 X 光结果确诊为 COVID-19。我们从病历中收集了有关人口统计学、疾病严重程度、症状、基础疾病(如糖尿病、高血压、冠心病、肥胖症、肾脏疾病/移植)以及住院时间、入住重症监护室和死亡率等结果的数据。采用卡方检验(chi-square)和费雪精确检验(Fisher's exact)分析了年龄、基础疾病和死亡率之间的关系:研究共纳入350名确诊为COVID-19的患者,平均年龄为(60.8±15.4)岁。56岁及以上年龄组发病率最高,占总人数的50%。在 COVID-19 患者中,糖尿病是最常见的基础疾病,占 31.4%。27.1%的患者患有高血压,17.1%的参与者患有冠心病(CHD)。此外,10.9%的参与者超重,其中30人曾经历过肾衰竭或肾移植。研究还发现,40%的糖尿病患者死亡,而冠心病患者的死亡率为 38.3%,超重患者的死亡率为 47.4%。高血压患者的死亡率为 43.2%,肾功能衰竭或肾移植患者的死亡风险显著增加,达到 83.3%。研究还显示,死亡率、年龄组和患者的基础疾病之间存在明显的直接关系:本研究的结果对预防性干预措施和政策的采用具有重要意义,特别是在使用日历年龄作为风险评估的关键标准方面。这些结果突出表明,有必要采取更精确、更有针对性的方法,对具有已识别风险因素的患者进行优先排序。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Tanaffos
Tanaffos Medicine-Critical Care and Intensive Care Medicine
CiteScore
1.10
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