The C-reactive protein-albumin-lymphocyte (CALLY) index is a useful predictor of postoperative complications in patients with a colonic stent for obstructive colorectal cancer: a Japanese multicenter study.

IF 1.7 4区医学 Q2 SURGERY

Surgery Today Pub Date : 2025-04-01 Epub Date: 2024-08-23 DOI:10.1007/s00595-024-02924-9

Toshio Shiraishi, Takashi Nonaka, Tetsuro Tominaga, Yuma Takamura, Kaido Oishi, Shintaro Hashimoto, Keisuke Noda, Rika Ono, Makoto Hisanaga, Hiroaki Takeshita, Mitsutoshi Ishii, Shosaburo Oyama, Kazuhide Ishimaru, Masaki Kunizaki, Terumitsu Sawai, Keitaro Matsumoto

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Abstract

Purpose: The C-reactive protein-albumin-lymphocyte (CALLY) index is a novel score that offers a good reflection of nutritional status, inflammatory response, and immune system status. The CALLY index is reported to correlate with the prognosis of various carcinomas. The purpose of the present study was to investigate the association between the CALLY index and the short-term prognosis of obstructive colorectal cancer managed with a colonic stent.

Methods: The subjects of this retrospective study were 263 patients who underwent colorectal resection after colonic stenting for obstructive colorectal cancer between 2016 and 2023. Patients were classified into a group with a low CALLY index (CALLY-L group, n = 85) and a group with a high (CALLY-H group, n = 178) CALLY index.

Results: The CALLY-L group had greater blood loss (53 mL vs 20 mL, p = 0.002) and higher poor performance status (PS3; 20% vs 10.1%, p = 0.033), open surgery (21.2% vs 7.3%, p = 0.001), distant metastases (41.2% vs 20.8%, p = 0.01), and postoperative complications (30.6% vs. 18.5%, p = 0.039) than the CALLY-H group. Multivariate analysis identified a prolonged operative time (odds ratio 1.983, 95% confidence interval 1.013-3.881; p = 0.045), greater blood loss (odds ratio 2.572, 95% confidence interval 1.291-5.129; p = 0.007) and a low CALLY index (odds ratio 1.961, 95% confidence interval 1.013-3.795; p = 0.045) as independent predictors of complications.

Conclusion: The CALLY index may be a useful predictor of postoperative complications of obstructive colorectal cancer.

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C-反应蛋白-白蛋白-淋巴细胞（CALLY）指数是阻塞性结直肠癌结肠支架患者术后并发症的有效预测指标：一项日本多中心研究。

目的：C-反应蛋白-白蛋白-淋巴细胞（CALLY）指数是一种新的评分方法，能很好地反映营养状况、炎症反应和免疫系统状态。据报道，CALLY 指数与各种癌症的预后相关。本研究旨在探讨 CALLY 指数与使用结肠支架治疗的阻塞性结直肠癌的短期预后之间的关系：这项回顾性研究的对象是2016年至2023年间因阻塞性结直肠癌接受结肠支架术后进行结直肠切除术的263名患者。患者被分为低CALLY指数组（CALLY-L组，n=85）和高CALLY指数组（CALLY-H组，n=178）：结果：与CALLY-H组相比，CALLY-L组失血量更大（53 mL vs 20 mL，p = 0.002），不良表现状态（PS3；20% vs 10.1%，p = 0.033）、开放手术（21.2% vs 7.3%，p = 0.001）、远处转移（41.2% vs 20.8%，p = 0.01）和术后并发症（30.6% vs. 18.5%，p = 0.039）更多。多变量分析发现，手术时间延长（几率比1.983，95%置信区间1.013-3.881；p = 0.045）、失血量增加（几率比2.572，95%置信区间1.291-5.129；p = 0.007）和CALLY指数低（几率比1.961，95%置信区间1.013-3.795；p = 0.045）是并发症的独立预测因素：结论：CALLY指数可能是阻塞性结直肠癌术后并发症的有效预测指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Surgery Today 医学-外科

CiteScore

4.90

自引率

4.00%

发文量

208

审稿时长

1 months

期刊介绍： Surgery Today is the official journal of the Japan Surgical Society. The main purpose of the journal is to provide a place for the publication of high-quality papers documenting recent advances and new developments in all fields of surgery, both clinical and experimental. The journal welcomes original papers, review articles, and short communications, as well as short technical reports("How to do it"). The "How to do it" section will includes short articles on methods or techniques recommended for practical surgery. Papers submitted to the journal are reviewed by an international editorial board. Field of interest: All fields of surgery.