The potential of Myrmecodia pendans in preventing complications of diabetes mellitus as an antidiabetic and antihyperlipidemic agent.

IF 0.9 Q3 VETERINARY SCIENCES

Open Veterinary Journal Pub Date : 2024-07-01 Epub Date: 2024-07-31 DOI:10.5455/OVJ.2024.v14.i7.10

Milahayati Daulay, Muhammad Syahputra, Mutiara Indah Sari, Tri Widyawati, Dwi Rita Anggraini

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引用次数: 0

Abstract

Background: Hyperglycemia in diabetes mellitus (DM) can lead to dyslipidemia, which is a risk factor for macrovascular complications such as heart disease and stroke. Aside from administering antidiabetic medications, DM treatment can also be achieved through the use of natural components, such as Myrmecodia pendans, commonly known as the ant nest plant (ANP).

Aim: This study aimed to investigate the impact of administering the ANP on the lipid profile of Wistar rats.

Methods: A group of 20 rats was divided into two categories: 6 rats served as healthy controls (H), while the remaining 14 rats were subjected to a high-lipid diet and streptozotocin to generate a model of type 2 diabetes mellitus (T2DM). The diabetic rats were divided into two groups: the DM group consisted of rats that did not receive any treatment, while the ANP group was administered the herb orally.

Results: The results revealed significant variations in triglyceride, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) levels among the three groups (p < 0.05). The post hoc test revealed disparities in triglyceride and LDL between those in the DM group and the ANP group (p < 0.05).

Conclusion: Myrmecodia pendans demonstrated the ability to decrease triglyceride and LDL, while increasing HDL levels in rats with T2DM.

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Myrmecodia pendans 作为一种抗糖尿病和抗高血脂药物在预防糖尿病并发症方面的潜力。

背景：糖尿病（DM）患者的高血糖可导致血脂异常，而血脂异常是心脏病和中风等大血管并发症的危险因素。除了服用抗糖尿病药物外，还可以通过使用天然成分来治疗 DM，如 Myrmecodia pendans（俗称蚂蚁窝植物（ANP））：方法：20 只大鼠分为两组：6只大鼠作为健康对照组（H），其余14只大鼠接受高脂饮食和链脲佐菌素治疗，以产生2型糖尿病（T2DM）模型。糖尿病大鼠被分为两组：DM 组大鼠未接受任何治疗，而 ANP 组大鼠则口服草药：结果显示，三组大鼠的甘油三酯、高密度脂蛋白（HDL）和低密度脂蛋白（LDL）水平存在明显差异（P < 0.05）。事后检验显示，DM 组和 ANP 组的甘油三酯和低密度脂蛋白存在差异（P < 0.05）：结论：Myrmecodia pendans能够降低T2DM大鼠的甘油三酯和低密度脂蛋白，同时提高高密度脂蛋白水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Veterinary Journal VETERINARY SCIENCES-

CiteScore

1.40

自引率

0.00%

发文量

112

审稿时长

12 weeks

期刊介绍： Open Veterinary Journal is a peer-reviewed international open access online and printed journal that publishes high-quality original research articles. reviews, short communications and case reports dedicated to all aspects of veterinary sciences and its related subjects. Research areas include the following: Infectious diseases of zoonotic/food-borne importance, applied biochemistry, parasitology, endocrinology, microbiology, immunology, pathology, pharmacology, physiology, epidemiology, molecular biology, immunogenetics, surgery, ophthalmology, dermatology, oncology and animal reproduction. All papers are peer-reviewed. Moreover, with the presence of well-qualified group of international referees, the process of publication will be done meticulously and to the highest standards.