Transcranial Direct Current Stimulation in Children With Anisometropic Amblyopia.

IF 2.3 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Clinical Neurophysiology Pub Date : 2024-08-23 DOI:10.1097/WNP.0000000000001110

Dina Ahmed El Salmawy, Reem Elhadidy, Asmaa Shuaib, Eman Ashraf Mahmoud, Mona M Nada

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引用次数: 0

Abstract

Background: Amblyopia is defined clinically as a difference in best-corrected visual acuity of two or more lines of acuity (0.2 logMAR) between the eyes. Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that can transiently alter the excitability of targeted brain areas in a polarity-specific manner.

Purpose: To detect the effect of tDCS on anisometropic amblyopia.

Methods: This is a randomized controlled trial conducted on 78 patients with anisometropic amblyopia from 4.5 to 12 years of age. All patients presented with monocular amblyopia. They were divided into three groups; each group received five sessions of tDCS (anodal tDCS, cathodal tDCS, and sham tDCS). The active electrode was placed over occipital midline and the reference over central midline. Pattern visual-evoked potentials and contrast sensitivity tests were conducted before, immediately after, and 1 week after tDCS.

Results: The amplitude of P100 was significantly decreased immediately after and 1 week after cathodal tDCS. The latency of P100 immediately after and 1 week after anodal tDCS was significantly decreased and increased significantly after cathodal tDCS. The amplitude of P100 and maximum and minimum contrast sensitivities were significantly increased immediately after and 1 week after anodal tDCS, and maximum contrast sensitivity was significantly decreased immediately after cathodal tDCS.

Conclusion: Anodal tDCS is a promising noninvasive modality for improvement of anisometropic amblyopia.

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经颅直流电刺激治疗各向异性弱视儿童。

背景：弱视的临床定义是两眼最佳矫正视力相差两行或两行以上（0.2 logMAR）。经颅直流电刺激（tDCS）是一种非侵入性脑刺激技术，能以极性特异的方式短暂改变目标脑区的兴奋性：这是一项随机对照试验，对象是 78 名 4.5 至 12 岁的各向异性弱视患者。所有患者均为单眼弱视。他们被分为三组，每组接受五次 tDCS 治疗（阳极 tDCS、阴极 tDCS 和假 tDCS）。主动电极位于枕骨中线，参考电极位于中央中线。在 tDCS 之前、之后和一周后分别进行了模式视觉诱发电位和对比敏感度测试：结果：阴极 tDCS 后和一周后，P100 的振幅明显下降。P100 的潜伏期在阳极 tDCS 后立即和一周后显著下降，在阴极 tDCS 后显著上升。P100 的振幅以及最大和最小对比敏感度在阳极 tDCS 后立即和一周后显著增加，而最大对比敏感度在阴极 tDCS 后立即显著降低：结论：阳极 tDCS 是一种很有希望改善异向性弱视的无创模式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Neurophysiology 医学-临床神经学

CiteScore

4.60

自引率

4.20%

发文量

198

审稿时长

6-12 weeks

期刊介绍： The Journal of Clinical Neurophysiology features both topical reviews and original research in both central and peripheral neurophysiology, as related to patient evaluation and treatment. Official Journal of the American Clinical Neurophysiology Society.