Cerebral blood flow alterations and host genetic association in individuals with long COVID: A transcriptomic-neuroimaging study.

IF 4.9 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-08-23 DOI:10.1177/0271678X241277621

Yao Wang, Ziwei Yang, Xiumei Zheng, Xiao Liang, Lin Wu, Chengsi Wu, Jiankun Dai, Yuan Cao, Meng Li, Fuqing Zhou

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引用次数: 0

Abstract

Neuroimaging studies have indicated that altered cerebral blood flow (CBF) was associated with the long-term symptoms of postacute sequelae of SARS-CoV-2 infection (PASC), also known as "long COVID". COVID-19 and long COVID were found to be strongly associated with host gene expression. Nevertheless, the relationships between altered CBF, clinical symptoms, and gene expression in the central nervous system (CNS) remain unclear in individuals with long COVID. This study aimed to explore the genetic mechanisms of CBF abnormalities in individuals with long COVID by transcriptomic-neuroimaging spatial association. Lower CBF in the left frontal-temporal gyrus was associated with higher fatigue and worse cognition in individuals with long COVID. This CBF pattern was spatially associated with the expression of 2,178 genes, which were enriched in the molecular functions and biological pathways of COVID-19. Our study suggested that lower CBF is associated with persistent clinical symptoms in long COVID individuals, possibly as a consequence of the complex interactions among multiple COVID-19-related genes, which contributes to our understanding of the impact of adverse CNS outcomes and the trajectory of development to long COVID.

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长COVID患者的脑血流改变与宿主基因相关性：转录组学-神经影像学研究。

神经影像学研究表明，脑血流（CBF）的改变与 SARS-CoV-2 感染急性期后遗症（PASC）（又称 "长 COVID"）的长期症状有关。研究发现，COVID-19 和长 COVID 与宿主基因表达密切相关。然而，长COVID患者的CBF改变、临床症状和中枢神经系统（CNS）基因表达之间的关系仍不清楚。本研究旨在通过转录组学与神经影像学的空间关联，探讨长程COVID患者CBF异常的遗传机制。在长COVID患者中，左侧额颞回较低的CBF与较高的疲劳度和较差的认知能力相关。这种CBF模式与2178个基因的表达存在空间关联，这些基因富集于COVID-19的分子功能和生物通路中。我们的研究表明，较低的CBF与长COVID患者的持续临床症状有关，这可能是多个COVID-19相关基因之间复杂相互作用的结果，有助于我们了解不良中枢神经系统结果的影响以及长COVID的发展轨迹。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cerebral Blood Flow and Metabolism 医学-内分泌学与代谢

CiteScore

12.00

自引率

4.80%

发文量

300

审稿时长

3 months

期刊介绍： JCBFM is the official journal of the International Society for Cerebral Blood Flow & Metabolism, which is committed to publishing high quality, independently peer-reviewed research and review material. JCBFM stands at the interface between basic and clinical neurovascular research, and features timely and relevant research highlighting experimental, theoretical, and clinical aspects of brain circulation, metabolism and imaging. The journal is relevant to any physician or scientist with an interest in brain function, cerebrovascular disease, cerebral vascular regulation and brain metabolism, including neurologists, neurochemists, physiologists, pharmacologists, anesthesiologists, neuroradiologists, neurosurgeons, neuropathologists and neuroscientists.