How to Identify and Manage High-Risk Smoldering Multiple Myeloma.

IF 4.7 2区 医学 Q1 ONCOLOGY
Current Oncology Reports Pub Date : 2024-11-01 Epub Date: 2024-08-23 DOI:10.1007/s11912-024-01596-5
Tarek H Mouhieddine
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引用次数: 0

Abstract

Purpose of review: It elucidates advancements in identifying and managing high-risk smoldering multiple myeloma (SMM), moving from observation strategies to intervention approaches. It highlights the significance of differentiating high-risk SMM from its less aggressive counterparts to prevent progression to multiple myeloma (MM).

Recent findings: Recent developments have improved SMM risk-stratification, integrating clinical, molecular and biological markers to identify high-risk individuals accurately. The advent of dynamic risk models that incorporate disease evolution and the application of novel diagnostic technologies are enhancing the understanding of SMM. Clinical trials exploring low to high intensity interventions, have shown promise in delaying MM onset and improving patient prognosis. There is a significant change in high-risk SMM management, leaning towards early intervention and precision medicine. The focus now is on refining these approaches, exploring new treatments, and proving the sustained benefits of early interventions to ultimately improve SMM patient care and outcomes.

如何识别和管理高风险多发性骨髓瘤。
综述的目的:它阐明了在识别和管理高危烟雾型多发性骨髓瘤(SMM)方面取得的进展,以及从观察策略到干预方法的转变。它强调了将高危SMM与侵袭性较低的SMM区分开来以防止其发展为多发性骨髓瘤(MM)的重要性:最新研究结果:最近的发展改善了SMM的风险分级,整合了临床、分子和生物标记物,以准确识别高危个体。结合疾病演变的动态风险模型的出现以及新型诊断技术的应用正在加深人们对SMM的了解。探索低强度到高强度干预措施的临床试验显示,这些措施有望延缓SMM发病并改善患者预后。SMM的高风险管理发生了重大变化,倾向于早期干预和精准医疗。现在的重点是完善这些方法,探索新的治疗方法,并证明早期干预的持续益处,以最终改善SMM患者的护理和预后。
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来源期刊
CiteScore
8.50
自引率
0.00%
发文量
187
审稿时长
6-12 weeks
期刊介绍: This journal aims to review the most important, recently published clinical findings in the field of oncology. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care of those affected by cancer. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as cancer prevention, leukemia, melanoma, neuro-oncology, and palliative medicine. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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