Oncologic Emergencies in Lung Cancer Patients and the Effects of SARS-COV2 Pandemic.

Q3 Medicine
Tanaffos Pub Date : 2023-04-01
Marta Alexandra Carvalho da Silva, Sara Campos Silva, Maria Joana Catarata, Eva Dias Padrão, Lurdes Ferreira
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引用次数: 0

Abstract

Background: Lung cancer is one of the most frequent neoplasms and is associated with serious oncologic emergencies (OE). We performed a retrospective study to characterize OE in lung cancer patients admitted to the pulmonology department to determine the effects of the SARS-CoV2 pandemic.

Materials and methods: A total number of 82 patients were admitted with an emergency, mostly brain metastasis (n=37; 45.1%), followed by superior vena cava syndrome (n=13; 15.9%), cardiac tamponade (n=7; 8.5%), large pleural effusion (n=7; 8.5%), severe pulmonary embolism (n=6; 7.3%), spinal cord syndrome (n=6; 7.3%), massive hemoptysis (n=3; 3.7%), stridor (n=2; 2.4%) and atelectasis (n=1; 1.2%). Clinical and pathological data were retrieved from clinical charts including demographic information, smoking status, cancer histology, clinical stage at diagnosis, anticancer treatment, time between LC diagnosis until the OE, outcomes of OE treatment, and overall survival after OE.

Results: The predominant histology was adenocarcinoma (n=59; 71.9%) and 86.8% of the patients (n=71) were in stage IV. OE was the disease presentation in 45.2% (n=37) and 6-month mortality was 75.6%. Neurologic emergencies were associated with a lower risk of 6-month mortality compared to cardiovascular and respiratory [OR 0.255 (CI 0.72-0.90), p=0.035)]. Younger patients (p=0.011), metastatic disease (p=0.02), no cancer treatment (p<0.001), and small cell carcinoma (SCLC) (p=0.016) had a shorter time between cancer diagnosis and the event.

Conclusion: OE occurred mostly in men with metastatic adenocarcinomas. Younger patients, SCLC, metastatic disease, and no cancer treatment were associated with a shorter time between lung cancer diagnosis until the occurrence of an OE and brain metastasis with a better prognosis. There were no differences between patients admitted in 2019 and 2020 that could be related to the access to healthcare services during the SARS-COV2 pandemic.

肺癌患者的肿瘤急症和 SARS-COV2 大流行的影响。
背景:肺癌是最常见的肿瘤之一,与严重的肿瘤急症(OE)有关。我们进行了一项回顾性研究,对肺科收治的肺癌患者的 OE 特征进行了分析,以确定 SARS-CoV2 大流行的影响:共有 82 名患者因急诊入院,大部分为脑转移(n=37;45.1%),其次为上腔静脉综合征(n=13;15.9%)、心脏填塞(n=7;8.5%)、大量胸腔积液(n=7;8.5%)、严重肺栓塞(n=6;7.3%)、脊髓综合征(n=6;7.3%)、大量咯血(n=3;3.7%)、呼吸困难(n=2;2.4%)和肺不张(n=1;1.2%)。临床和病理数据均来自临床病历,包括人口统计学信息、吸烟状况、癌症组织学、诊断时的临床分期、抗癌治疗、从确诊LC到OE的时间、OE治疗的结果以及OE后的总生存率:主要组织学类型为腺癌(59 人;71.9%),86.8%的患者(71 人)处于 IV 期。45.2%的患者(37人)以OE为发病表现,6个月死亡率为75.6%。与心血管和呼吸系统急症相比,神经系统急症的 6 个月死亡率风险较低[OR 0.255 (CI 0.72-0.90), p=0.035]。年轻患者(P=0.011)、转移性疾病(P=0.02)、未接受过癌症治疗(P结论:OE主要发生在患有转移性腺癌的男性患者中。较年轻的患者、SCLC、转移性疾病和未接受癌症治疗与肺癌诊断到发生 OE 和脑转移的时间较短和预后较好有关。2019年和2020年收治的患者之间没有差异,这可能与SARS-COV2大流行期间获得医疗服务的情况有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Tanaffos
Tanaffos Medicine-Critical Care and Intensive Care Medicine
CiteScore
1.10
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