Dual-responsive nanoparticles constructed using light- and redox-responsive linkages†

IF 3.9 2区化学 Q2 POLYMER SCIENCE

Polymer Chemistry Pub Date : 2024-09-18 DOI:10.1039/d4py00824c

Yufu Wang , Changhe Zhang , Manjiri Choudhari , Sarah S. Kermaniyan , Chris Ritchie , Georgina K. Such

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Abstract

Stimuli-responsive nanoparticles have garnered significant interest for advanced materials design and development in areas such as biomedicine, sensing, and energy. Recent studies have demonstrated that integrating multiple functionalities into a single nanoparticle structure is a crucial approach for engineering multi-responsive properties. In this study, light- and redox-responsive nanoparticles were synthesized using a simple one-pot emulsion polymerization utilizing mild thiol-disulfide exchange reactions to direct the self-assembly process. Poly(disulfide) bonds were formed during this process and comprised the core part of the nanoparticles, enabling redox responsiveness upon disulfide cleavage. A photochromic diarylethene (DAE) was also covalently attached within the hydrophobic poly(disulfide) matrix, imparting light-responsive behavior to the particles. Tuning the nanoparticle composition by varying the thiol/DAE ratio enabled a correlation between particle composition and disassembly kinetics to be established. The DAE retained photochromic activity in the nanoparticles, however, the switching efficiency was diminished when compared to the monomer due to the matrix effect.

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利用光和氧化还原反应连接构建的双反应纳米粒子

刺激响应型纳米粒子在生物医学、传感和能源等领域的先进材料设计和开发方面引起了极大的兴趣。最近的研究表明，将多种功能集成到单个纳米粒子结构中是设计多响应特性的关键方法。本研究利用温和的硫醇-二硫交换反应指导自组装过程，通过简单的一锅乳液聚合法合成了光和氧化还原反应纳米粒子。在此过程中形成了聚（二硫化物）键，并构成了纳米粒子的核心部分，从而在二硫化物裂解时实现了氧化还原反应。疏水性聚（二硫化物）基质中还共价连接了一种光致变色的二元蒽（DAE），使颗粒具有光响应特性。通过改变硫醇/DAE 的比例来调节纳米粒子的组成，从而建立了粒子组成与分解动力学之间的相关性。与单体相比，DAE 在纳米粒子中保留了光致变色活性，但由于基质效应，其开关效率有所降低。

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来源期刊

Polymer Chemistry POLYMER SCIENCE-

CiteScore

8.60

自引率

8.70%

发文量

535

审稿时长

1.7 months

期刊介绍： Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.