Exosome regulation by Rubicon in ageing

IF 17.3 1区生物学 Q1 CELL BIOLOGY

Nature Cell Biology Pub Date : 2024-08-22 DOI:10.1038/s41556-024-01482-z

Yan Zhen, Harald Stenmark

引用次数: 0

Abstract

Autophagy decreases with age, and this is in part attributed to increasing levels of the autophagy-suppressing protein Rubicon. Cell biologists now find another ageing-associated function for Rubicon — the release of exosomes containing microRNAs that control senescence and longevity.

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外泌体在衰老过程中受卢比肯的调控

自噬会随着年龄的增长而减少，这部分归因于自噬抑制蛋白Rubicon水平的增加。细胞生物学家现在发现了 Rubicon 的另一个与衰老相关的功能--释放含有控制衰老和长寿的 microRNA 的外泌体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Cell Biology 生物-细胞生物学

CiteScore

28.40

自引率

0.90%

发文量

219

审稿时长

3 months

期刊介绍： Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology