Correlation between inflammatory cytokines and the likelihood of developing multiple types of digestive system cancers: A Mendelian randomization study

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2024-08-21 DOI:10.1016/j.cyto.2024.156735

Su-Lan Chen , Bin Zhang , Song Wang , Ming Yang , Qiao-Hui Shen , Rui Zhang , Zhuang Xiong , Yan Leng

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引用次数: 0

Abstract

Objective

Inflammatory cytokines have been linked to digestive system cancers, yet their exact causal connection remains uncertain. Consequently, we conducted a Mendelian randomization (MR) analysis to gauge how inflammatory cytokines are linked to the risk of five prevalent digestive system cancers (DSCs).

Methods

We collected genetic variation data for 41 inflammatory cytokines from genome-wide association studies (GWAS), and the results data for five common diseases from the Finnish database. Our primary analytical approach involved employing the inverse-variance weighted, residual sum (IVW) method, complemented by the MR-Egger method, the weighted median method, simple mode analysis, and weighted mode analysis as supplementary analytical techniques. Furthermore, we conducted multiple sensitivity analyses.

Results

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), macrophage colony-stimulating factor (M-CSF), and interleukin (IL)-18 showed a negative association with the risk of hepatocellular carcinoma. Conversely, TRAIL was inversely linked to the risk of gastric cancer, while IL-16 exhibited a positive correlation with gastric cancer risk. Stem cell factor (SCF) acted as a protective factor against pancreatic cancer. For colorectal cancer, IL-7, IL-9, IL-13, and vascular endothelial growth factor (VEGF) were identified as risk factors. Notably, our results did not indicate a significant correlation between inflammatory cytokines and the risk of esophageal cancer.

Conclusion

Our research unveils potential connections between 41 inflammatory cytokines and the risk of five common DSCs through a MR analysis. These associations offer valuable insights that could aid in the development of diagnostic biomarkers and the identification of novel therapeutic targets for DSCs.

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炎性细胞因子与罹患多种消化系统癌症的可能性之间的相关性：孟德尔随机研究

目的炎性细胞因子与消化系统癌症有关，但其确切的因果关系仍不确定。因此，我们进行了孟德尔随机化（MR）分析，以评估炎性细胞因子与五种流行的消化系统癌症（DSCs）风险之间的联系。方法我们从全基因组关联研究（GWAS）中收集了 41 种炎性细胞因子的遗传变异数据，并从芬兰数据库中收集了五种常见疾病的结果数据。我们的主要分析方法是采用反方差加权残差和（IVW）法，并辅以 MR-Egger 法、加权中位数法、简单模式分析和加权模式分析作为辅助分析技术。结果肿瘤坏死因子相关凋亡诱导配体（TRAIL）、巨噬细胞集落刺激因子（M-CSF）和白细胞介素（IL）-18与肝细胞癌风险呈负相关。相反，TRAIL 与胃癌风险成反比，而 IL-16 与胃癌风险呈正相关。干细胞因子（SCF）是胰腺癌的保护因子。就大肠癌而言，IL-7、IL-9、IL-13 和血管内皮生长因子（VEGF）被认为是风险因素。结论我们的研究通过磁共振分析揭示了 41 种炎症细胞因子与五种常见的 DSCs 风险之间的潜在联系。这些关联提供了有价值的见解，有助于开发诊断生物标记物和确定 DSCs 的新型治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.