Correlations Between Bone Turnover Marker Concentrations and Maxillary and Mandibular Cancellous Hounsfield Units: A Cross-Sectional Study.

Abstract

Purpose: To investigate the associations between the concentrations of bone turnover markers and maxillary and mandibular cancellous Hounsfield units (HUs) to determine whether bone turnover marker (BTM) assessments are effective for preoperative examinations for implant treatment.

Materials and methods: The study included 94 patients (37 males and 57 females) with a mean age of 62.0 ± 11.9 years. Spearman's rank correlation and multivariate linear regression coefficients were used to determine the associations between the BTMs and maxillary and mandibular cancellous HUs.

Results: Multivariate bias correction showed that the concentrations of bone-specific alkaline phosphatase, procollagen type 1 N-terminal propeptide, and deoxypyridinoline were negatively associated with the maxillary HUs. The concentration of undercarboxylated osteocalcin tended to be negatively associated with the maxillary HUs but was not significant. The concentrations of deoxypyridinoline and tartrate-resistant acid phosphatase 5b were significantly negatively associated, and the concentrations of bone-specific alkaline phosphatase and procollagen type 1 N-terminal propeptide only tended to be negatively associated, with the mandibular HUs.

Conclusions: Several bone formation and resorption markers were negatively correlated with the maxillary and mandibular HUs. The BTM measurement was effective for preoperative examination for implant treatment.