Contributing role of metabolic genes APOE, FTO, and LPL in the development of atrial fibrillation: insights from a case-control study.

Revista da Associacao Medica Brasileira (1992) Pub Date : 2024-08-16 eCollection Date: 2024-01-01 DOI:10.1590/1806-9282.20240263

Saira Rafaqat, Saima Sharif, Shagufta Naz, Dimitrios Patoulias, Aleksandra Klisic

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Abstract

Objective: The aim of the study was to examine the expression profile of genes (APOE, FTO, and LPL) associated with metabolic syndrome (MetS) in subjects with concomitant atrial fibrillation (AF).

Methods: A total of 690 subjects were categorized into control, AF without MetS, and AF with MetS.

Results: The expression profiles of the APOE, FTO, and LPL genes were decreased in AF subjects and AF subjects with MetS as compared to the controls. In AF without the MetS group, an inverse relationship was found between the expression of the LPL gene with body mass index (BMI) and a positive relationship with creatine kinase-MB, whereas expression of the FTO gene was inversely associated with fasting blood glucose and positively with cardiac troponin I in AF suffering from MetS. Expression of the LPL gene was directly linked with systolic blood pressure (SBP) and high-density lipoprotein-cholesterol (HDL-C), whereas an inverse correlation with heart rate and expression of the FTO gene in AF with MetS were shown. The expression of the LPL gene was inversely related to BMI in subjects with AF. The expression of the LPL gene was positively correlated with SBP and HDL-C and negatively correlated with heart rate, while the expression of the FTO gene was an important predictor of AF with MetS.

Conclusion: The decreased expression of APOE, FTO, and LPL genes in AF with and without MetS indicates their potential contributing role in the pathogenesis of AF.

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代谢基因 APOE、FTO 和 LPL 在心房颤动发病中的作用：一项病例对照研究的启示。

研究目的该研究旨在检测伴有心房颤动（AF）的受试者中与代谢综合征（MetS）相关的基因（APOE、FTO和LPL）的表达谱：方法：将 690 名受试者分为对照组、无代谢综合征的房颤组和有代谢综合征的房颤组：结果：与对照组相比，房颤受试者和有 MetS 的房颤受试者的 APOE、FTO 和 LPL 基因表达谱均有所下降。在无 MetS 的房颤组中，LPL 基因的表达与体重指数（BMI）呈反向关系，与肌酸激酶-MB 呈正向关系；而在有 MetS 的房颤组中，FTO 基因的表达与空腹血糖呈反向关系，与心肌肌钙蛋白 I 呈正向关系。在患有代谢性疾病的房颤患者中，LPL 基因的表达与收缩压（SBP）和高密度脂蛋白胆固醇（HDL-C）直接相关，而与心率和 FTO 基因的表达呈反相关。在房颤受试者中，LPL 基因的表达与体重指数成反比。LPL 基因的表达与 SBP 和 HDL-C 呈正相关，与心率呈负相关，而 FTO 基因的表达则是预测房颤合并 MetS 的重要指标：结论：APOE、FTO 和 LPL 基因在有 MetS 和无 MetS 房颤患者中的表达减少表明，它们在房颤的发病机制中起着潜在的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Revista da Associacao Medica Brasileira (1992)

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