Management of bilateral head and neck paragangliomas at a single-institution across four decades.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Nikhil Bellamkonda, Evan L Tooker, Anne Naumer, Luke O Buchmann, Wendy Kohlmann, Hilary C McCrary, Neil S Patel, Mana Espahbodi
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引用次数: 0

Abstract

Background: Bilateral head and neck paragangliomas (HNPGLs) require nuanced management to balance tumor control with functional preservation.

Methods: All patients seen at a single-institution for bilateral paraganglioma between 1983 and 2023 were retrospectively reviewed. Demographics, genetic testing results, and tumor characteristics were analyzed and compared to treatment modality and cranial nerve outcomes.

Results: There were 49 patients with 116 tumors (90 carotid body tumors [CBTs], 15 vagal paragangliomas [VPs], and 11 jugular paragangliomas [JPs]). Twenty-six patients had SDH pathologic variants (PV). Surgical management was more commonly utilized in younger patients (OR: 0.97, 95% CI: 0.950-0.992) and for JPs (OR: 9, 95% CI: 1.386-58.443). In surgical cases, CBTs had a lower risk of postoperative cranial nerve deficits compared to JPs and VPs (OR: 0.095, 95% CI: 0.013-0.692).

Conclusions: Younger patients with bilateral HNPGLs, especially those with JP and CBT, are more often treated with surgery. CBTs have lowest risk of cranial nerve deficits after surgery.

一家医疗机构四十年来对双侧头颈部副神经节瘤的治疗。
背景:双侧头颈部副神经节瘤(HNPGLs)需要细致入微的管理,以平衡肿瘤控制与功能保护:方法:回顾性研究了1983年至2023年间在一家机构就诊的所有双侧副神经节瘤患者。对人口统计学、基因检测结果和肿瘤特征进行分析,并将其与治疗方式和颅神经结果进行比较:共有49名患者,116个肿瘤(90个颈动脉体瘤[CBTs]、15个迷走神经旁神经节瘤[VPs]和11个颈静脉旁神经节瘤[JPs])。26例患者有SDH病理变异(PV)。手术治疗更多用于年轻患者(OR:0.97,95% CI:0.950-0.992)和 JPs(OR:9,95% CI:1.386-58.443)。在手术病例中,CBT与JP和VP相比,术后出现颅神经缺损的风险较低(OR:0.095,95% CI:0.013-0.692):结论:年轻的双侧 HNPGLs 患者,尤其是 JP 和 CBT 患者,更常接受手术治疗。CBT患者术后出现颅神经缺损的风险最低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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