Management of bilateral head and neck paragangliomas at a single-institution across four decades.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-08-21 DOI:10.1002/hed.27923

Nikhil Bellamkonda, Evan L Tooker, Anne Naumer, Luke O Buchmann, Wendy Kohlmann, Hilary C McCrary, Neil S Patel, Mana Espahbodi

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Abstract

Background: Bilateral head and neck paragangliomas (HNPGLs) require nuanced management to balance tumor control with functional preservation.

Methods: All patients seen at a single-institution for bilateral paraganglioma between 1983 and 2023 were retrospectively reviewed. Demographics, genetic testing results, and tumor characteristics were analyzed and compared to treatment modality and cranial nerve outcomes.

Results: There were 49 patients with 116 tumors (90 carotid body tumors [CBTs], 15 vagal paragangliomas [VPs], and 11 jugular paragangliomas [JPs]). Twenty-six patients had SDH pathologic variants (PV). Surgical management was more commonly utilized in younger patients (OR: 0.97, 95% CI: 0.950-0.992) and for JPs (OR: 9, 95% CI: 1.386-58.443). In surgical cases, CBTs had a lower risk of postoperative cranial nerve deficits compared to JPs and VPs (OR: 0.095, 95% CI: 0.013-0.692).

Conclusions: Younger patients with bilateral HNPGLs, especially those with JP and CBT, are more often treated with surgery. CBTs have lowest risk of cranial nerve deficits after surgery.

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一家医疗机构四十年来对双侧头颈部副神经节瘤的治疗。

背景：双侧头颈部副神经节瘤（HNPGLs）需要细致入微的管理，以平衡肿瘤控制与功能保护：方法：回顾性研究了1983年至2023年间在一家机构就诊的所有双侧副神经节瘤患者。对人口统计学、基因检测结果和肿瘤特征进行分析，并将其与治疗方式和颅神经结果进行比较：共有49名患者，116个肿瘤（90个颈动脉体瘤[CBTs]、15个迷走神经旁神经节瘤[VPs]和11个颈静脉旁神经节瘤[JPs]）。26例患者有SDH病理变异（PV）。手术治疗更多用于年轻患者（OR：0.97，95% CI：0.950-0.992）和 JPs（OR：9，95% CI：1.386-58.443）。在手术病例中，CBT与JP和VP相比，术后出现颅神经缺损的风险较低（OR：0.095，95% CI：0.013-0.692）：结论：年轻的双侧 HNPGLs 患者，尤其是 JP 和 CBT 患者，更常接受手术治疗。CBT患者术后出现颅神经缺损的风险最低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464