CLINICOPATHOLOGIC CHANGES OF VITREOMACULAR INTERFACE IN IDIOPATHIC EPIRETINAL MEMBRANE WITH DISORGANIZATION OF RETINAL INNER LAYERS.

IF 2.3 2区医学 Q2 OPHTHALMOLOGY

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2024-09-01 DOI:10.1097/IAE.0000000000004162

Huanhuan Li, Yan Liu, Jinghong Yao, Jiusheng Zheng, Yanting Yang, Hui Li, Fang Wang, Yao Liu

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引用次数: 0

Abstract

Purpose: To compare the pathological characteristics of the vitreomacular interface of the idiopathic epiretinal membrane with and without disorganization of retinal inner layers (DRIL) and to correlate with clinical data.

Methods: In this clinicopathologic study, the samples of epiretinal membrane and internal limiting membrane were extracted from DRIL(+) (19 eyes) and DRIL(-) (22 eyes) idiopathic epiretinal membrane eyes. Ultrathin series sectioning for transmission electron microscopy was observed and correlated with surgery status and prognosis.

Results: All idiopathic epiretinal membrane eyes presented fibrocellular membranes accompanied by vitreous collagen, glial cells, and myofibroblasts, regardless of association with DRIL. A robust signal indicative of Collagen Type VI was observed in eyes DRIL(-), whereas Collagen Type I was discovered in DRIL eyes. Cell debris and microvascular basement membrane were seen on the retinal side of DRIL eyes and a larger cell count on the vitreous side. These have more intraoperative complications and less surgery benefit.

Conclusion: Although internal limiting membrane peeling seems important, the histopathologic findings underscore the potential for retinal injury in DRIL(+) idiopathic epiretinal membrane eyes. This suggests that further research is needed to investigate individual preoperative assessment and to modify surgical procedures.

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特发性视网膜外膜伴有视网膜内层紊乱的玻璃体-视网膜界面的临床病理变化。

目的：比较有和无视网膜内层紊乱（DRIL）的特发性视网膜外膜玻璃体-玻璃体界面的病理特征，并将其与临床数据相关联：在这项临床病理学研究中，从DRIL(+)（19眼）和DRIL(-)（22眼）特发性视网膜外膜眼球中提取了视网膜外膜和内缘膜样本。观察透射电子显微镜下的超薄系列切片，并将其与手术状态和预后相关联：结果：所有特发性视网膜外膜眼球都出现了伴有玻璃体胶原、胶质细胞和肌成纤维细胞的纤维膜，与 DRIL 无关。在 DRIL（-）眼中观察到指示 VI 型胶原的强信号，而在 DRIL 眼中发现了 I 型胶原。在 DRIL 眼睛的视网膜一侧可以看到细胞碎片和微血管基底膜，而玻璃体一侧的细胞数量较多。结论：结论：虽然内层限局性膜剥离似乎很重要，但组织病理学发现强调了DRIL（+）特发性视网膜外膜眼视网膜损伤的可能性。结论：尽管内层限局性膜剥离似乎很重要，但组织病理学发现强调了DRIL（+）特发性视网膜外膜眼视网膜损伤的可能性，这表明需要进一步研究个体术前评估和修改手术程序。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Retina-The Journal of Retinal and Vitreous Diseases 医学-眼科学

CiteScore

5.70

自引率

9.10%

发文量

554

审稿时长

3-6 weeks

期刊介绍： RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice. In addition to regular reports from clinical and basic science investigators, RETINA® publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards. Issues are abundantly illustrated in vivid full color. Published 12 times per year, RETINA® is truly a “must have” publication for anyone connected to this field.