Navigating the labyrinth of long non-coding RNAs in colorectal cancer: From chemoresistance to autophagy.

IF 2.5 4区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Jia-Mei Yu, Chong-Qi Sun, Huan-Huan Xu, Ya-Li Jiang, Xing-Yu Jiang, Si-Qi Ni, Ting-Yu Zhao, Ling-Xiang Liu
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引用次数: 0

Abstract

Long non-coding RNAs (lncRNAs), with transcript lengths exceeding 200 nucleotides and little or no protein-coding capacity, have been found to impact colorectal cancer (CRC) through various biological processes. LncRNA expression can regulate autophagy, which plays dual roles in the initiation and progression of cancers, including CRC. Abnormal expression of lncRNAs is associated with the emergence of chemoresistance. Moreover, it has been confirmed that targeting autophagy through lncRNA regulation could be a viable approach for combating chemoresistance. Two recent studies titled "Human β-defensin-1 affects the mammalian target of rapamycin pathway and autophagy in colon cancer cells through long non-coding RNA TCONS_00014506" and "Upregulated lncRNA PRNT promotes progression and oxaliplatin resistance of colorectal cancer cells by regulating HIPK2 transcription" revealed novel insights into lncRNAs associated with autophagy and oxaliplatin resistance in CRC, respectively. In this editorial, we particularly focus on the regulatory role of lncRNAs in CRC-related autophagy and chemoresistance since the regulation of chemotherapeutic sensitivity by intervening with the lncRNAs involved in the autophagy process has become a promising new approach for cancer treatment.

探索结直肠癌中长非编码 RNA 的迷宫:从化疗抗性到自噬。
长非编码 RNA(lncRNA)的转录本长度超过 200 个核苷酸,几乎不具有编码蛋白质的能力,已被发现可通过各种生物学过程影响结直肠癌(CRC)。LncRNA 的表达可调控自噬,而自噬在癌症(包括 CRC)的发生和发展过程中扮演着双重角色。lncRNA 的异常表达与化疗耐药性的出现有关。此外,通过lncRNA调控自噬可能是对抗化疗耐药性的一种可行方法。最近两项题为 "Human β-defensin-1 affects the mammalian target of rapamycin pathway and autophagy in colon cancer cells through long non-coding RNA TCONS_00014506 "和 "Upregulated lncRNA PRNT promotes progression and oxaliplatin resistance of colorectal cancer cells by regulating HIPK2 transcription "的研究分别揭示了与CRC自噬和奥沙利铂耐药性相关的lncRNA的新见解。在这篇社论中,我们特别关注lncRNAs在CRC相关自噬和化疗耐药中的调控作用,因为通过干预参与自噬过程的lncRNAs来调节化疗敏感性已成为一种很有前景的癌症治疗新方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
World Journal of Gastrointestinal Oncology
World Journal of Gastrointestinal Oncology Medicine-Gastroenterology
CiteScore
4.20
自引率
3.30%
发文量
1082
期刊介绍: The World Journal of Gastrointestinal Oncology (WJGO) is a leading academic journal devoted to reporting the latest, cutting-edge research progress and findings of basic research and clinical practice in the field of gastrointestinal oncology.
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