Immune-related gene characteristics: A new chapter in precision treatment of gastric cancer.

IF 2.5 4区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Lei Gao, Qiang Lin
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引用次数: 0

Abstract

Gastric cancer ranks as the sixth most prevalent cancer worldwide. In recent research within the realm of gastric cancer treatment, the identification and application of immune-related genetic features have emerged as groundbreaking advancements. The study by Ma et al, which developed a prognostic model based on 10 genes, categorizes patients into high and low-risk groups to predict their responsiveness to immune checkpoint inhibitor therapy. This research underscores the potential of immune-related genes as biomarkers for personalized treatment, offering insights into tumor mutation burden and immune phenotype scores. We advocate for further validation, understanding of biological mechanisms, and integration of diverse datasets to enhance the model's predictive accuracy and clinical application, marking a significant step towards personalized and precise treatment for gastric cancer.

免疫相关基因特征:胃癌精准治疗的新篇章。
胃癌是全球发病率第六高的癌症。在胃癌治疗领域的最新研究中,免疫相关基因特征的识别和应用取得了突破性进展。Ma 等人的研究基于 10 个基因建立了一个预后模型,将患者分为高危和低危两组,以预测他们对免疫检查点抑制剂治疗的反应性。这项研究强调了免疫相关基因作为个性化治疗生物标志物的潜力,为肿瘤突变负荷和免疫表型评分提供了见解。我们主张进一步验证、了解生物机制并整合不同的数据集,以提高模型的预测准确性和临床应用,从而向胃癌的个性化精准治疗迈出重要一步。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
World Journal of Gastrointestinal Oncology
World Journal of Gastrointestinal Oncology Medicine-Gastroenterology
CiteScore
4.20
自引率
3.30%
发文量
1082
期刊介绍: The World Journal of Gastrointestinal Oncology (WJGO) is a leading academic journal devoted to reporting the latest, cutting-edge research progress and findings of basic research and clinical practice in the field of gastrointestinal oncology.
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