Synthetic biology approaches and bioseparations in syngas fermentation.

IF 14.3 1区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Naorem Bela Devi, Gopal Pugazhenthi, Kannan Pakshirajan
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引用次数: 0

Abstract

Fossil fuel use drives greenhouse gas emissions and climate change, highlighting the need for alternatives like biomass-derived syngas. Syngas, mainly H2 and CO, is produced via biomass gasification and offers a solution to environmental challenges. Syngas fermentation through the Wood-Ljungdahl pathway yields valuable chemicals under mild conditions. However, challenges in scaling up persist due to issues like unpredictable syngas composition and microbial fermentation contamination. This review covers advancements in genetic tools and metabolic engineering to expand product range, highlighting crucial enabling technologies that expedite strain development for acetogens and other non-model organisms. This review paper provides an in-depth exploration of syngas fermentation, covering microorganisms, gas composition effects, separation techniques, techno economic analysis, and commercialization efforts.

合成气发酵中的合成生物学方法和生物分离。
化石燃料的使用加剧了温室气体排放和气候变化,这凸显了对生物质合成气等替代品的需求。合成气(主要是 H2 和 CO)通过生物质气化产生,为应对环境挑战提供了解决方案。通过伍德-荣格达尔途径进行合成气发酵,可以在温和的条件下产生有价值的化学物质。然而,由于合成气成分不可预测和微生物发酵污染等问题,扩大规模仍面临挑战。本综述介绍了基因工具和代谢工程在扩大产品范围方面取得的进展,重点介绍了加快乙炔原和其他非模式生物菌种开发的关键使能技术。本综述对合成气发酵进行了深入探讨,涉及微生物、气体成分影响、分离技术、技术经济分析和商业化努力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Trends in biotechnology
Trends in biotechnology 工程技术-生物工程与应用微生物
CiteScore
28.60
自引率
1.20%
发文量
198
审稿时长
1 months
期刊介绍: Trends in Biotechnology publishes reviews and perspectives on the applied biological sciences, focusing on useful science applied to, derived from, or inspired by living systems. The major themes that TIBTECH is interested in include: Bioprocessing (biochemical engineering, applied enzymology, industrial biotechnology, biofuels, metabolic engineering) Omics (genome editing, single-cell technologies, bioinformatics, synthetic biology) Materials and devices (bionanotechnology, biomaterials, diagnostics/imaging/detection, soft robotics, biosensors/bioelectronics) Therapeutics (biofabrication, stem cells, tissue engineering and regenerative medicine, antibodies and other protein drugs, drug delivery) Agroenvironment (environmental engineering, bioremediation, genetically modified crops, sustainable development).
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