Cancer incidence and mortality after a first-ever venous thrombosis: a cohort study in northern Sweden.

IF 2.6 4区医学 Q2 HEMATOLOGY

Thrombosis Journal Pub Date : 2024-08-21 DOI:10.1186/s12959-024-00646-z

Lovisa Hägg, Felicia Ehrs, Marcus Lind, Magdalena Johansson

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引用次数: 0

Abstract

Background: Venous thromboembolism (VTE) has a high mortality rate and can be the first manifestation of cancer. We investigated the incidence of cancer after first-ever VTE and the association between VTE and all-cause mortality.

Methods: A Swedish cohort study that included 105,997 participants without previous cancer who underwent a health examination from 1985-2014 was conducted. Manually validated first-ever VTE events, incident cancer according to the Swedish cancer registry, and mortality were registered. Participants were followed until September 5, 2014.

Results: The mean age at inclusion was 46.2 years, and 50.3% of participants were female. We identified 1303 persons in the cohort with a VTE and no previous cancer. Among these, 179 (13.7%) were diagnosed with cancer after the VTE event, resulting in a cancer incidence of 26.4 (95% CI 22.8-30.6) cases per 1000 person-years. The incidence was highest during the first 6 months after the VTE. In the study population, VTE was associated with an increased risk of cancer (HR 1.95 [95% CI 1.67-2.29] in a multivariable model). VTE was also associated with an increased risk of death (HR 6.30 [95% CI 5.82-6.81]) in a multivariable model). There was an interaction between sex and VTE in relation to both risk of cancer and mortality, with a stronger association in women.

Conclusions: The incidence of cancer is high after first-ever VTE, especially close to the VTE event. VTE seems to be a stronger risk marker in women than in men for both cancer and death.

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首次静脉血栓形成后的癌症发病率和死亡率：瑞典北部的一项队列研究。

背景：静脉血栓栓塞症（VTE）的死亡率很高，而且可能是癌症的首发症状。我们调查了首次发生 VTE 后的癌症发病率以及 VTE 与全因死亡率之间的关系：瑞典的一项队列研究纳入了 1985-2014 年间接受健康检查的 105,997 名既往未患过癌症的参与者。研究人员登记了经人工验证的首次发生 VTE 事件、瑞典癌症登记处的癌症发病率和死亡率。对参与者进行了跟踪调查，直至 2014 年 9 月 5 日：纳入时的平均年龄为 46.2 岁，50.3% 的参与者为女性。我们在队列中发现了 1303 名曾患过 VTE 且未患过癌症的人。其中有 179 人（13.7%）在发生 VTE 事件后被确诊为癌症，癌症发病率为每千人年 26.4 例（95% CI 22.8-30.6 例）。在 VTE 发生后的头 6 个月中，癌症发病率最高。在研究人群中，VTE 与癌症风险增加有关（在多变量模型中，HR 为 1.95 [95% CI 1.67-2.29]）。在多变量模型中，VTE 还与死亡风险增加有关（HR 6.30 [95% CI 5.82-6.81]）。在癌症风险和死亡率方面，性别与 VTE 之间存在交互作用，女性的相关性更强：结论：首次发生 VTE 后癌症的发病率很高，尤其是在 VTE 事件附近。在癌症和死亡风险方面，女性的 VTE 似乎比男性的风险标志物更强。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Thrombosis Journal Medicine-Hematology

CiteScore

3.80

自引率

3.20%

发文量

审稿时长

16 weeks

期刊介绍： Thrombosis Journal is an open-access journal that publishes original articles on aspects of clinical and basic research, new methodology, case reports and reviews in the areas of thrombosis. Topics of particular interest include the diagnosis of arterial and venous thrombosis, new antithrombotic treatments, new developments in the understanding, diagnosis and treatments of atherosclerotic vessel disease, relations between haemostasis and vascular disease, hypertension, diabetes, immunology and obesity.