Effects of glucocorticoid replacement therapy in patients with pituitary disease: A new perspective for personalized replacement therapy.

IF 6.9 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-10-01 Epub Date: 2024-08-22 DOI:10.1007/s11154-024-09898-6

Sabrina Chiloiro, Alessandra Vicari, Ginevra Mongelli, Flavia Costanza, Antonella Giampietro, Pier Paolo Mattogno, Liverana Lauretti, Alessandro Olivi, Laura De Marinis, Francesco Doglietto, Antonio Bianchi, Alfredo Pontecorvi

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引用次数: 0

Abstract

Secondary adrenal insufficiency (SAI) is an endocrine disorder due to impaired secretion of ACTH resulting from any disease affecting the pituitary gland. Glucocorticoid replacement therapy is mandatory to ensure patient survival, haemodynamic stability, and quality of life. In fact, a correct dose adjustement is mandatory due to the fact that inappropriately low doses expose patients to hypoadrenal crisis, while inappropriately high doses contribute to glucose metabolic and cardiovascular deterioration. This review analyses the current evidence from available publications on the epidemiology and aetiology of SAI and examines the association between glucocorticoid replacement therapy and glucometabolic and cardiovascular effects.

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糖皮质激素替代疗法对垂体疾病患者的影响：个性化替代疗法的新视角

继发性肾上腺功能不全（SAI）是一种内分泌失调症，是由于任何影响垂体的疾病导致促肾上腺皮质激素（ACTH）分泌受损所致。糖皮质激素替代治疗是确保患者生存、血流动力学稳定和生活质量的必要手段。事实上，正确的剂量调整是必须的，因为不适当的低剂量会使患者面临肾上腺功能减退危象，而不适当的高剂量则会导致糖代谢和心血管恶化。本综述分析了现有出版物中关于 SAI 流行病学和病因学的证据，并研究了糖皮质激素替代疗法与糖代谢和心血管效应之间的关联。

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来源期刊

Reviews in Endocrine & Metabolic Disorders 医学-内分泌学与代谢

CiteScore

14.70

自引率

1.20%

发文量

审稿时长

>12 weeks

期刊介绍： Reviews in Endocrine and Metabolic Disorders is an international journal dedicated to the field of endocrinology and metabolism. It aims to provide the latest advancements in this rapidly advancing field to students, clinicians, and researchers. Unlike other journals, each quarterly issue of this review journal focuses on a specific topic and features ten to twelve articles written by world leaders in the field. These articles provide brief overviews of the latest developments, offering insights into both the basic aspects of the disease and its clinical implications. This format allows individuals in all areas of the field, including students, academic clinicians, and practicing clinicians, to understand the disease process and apply their knowledge to their specific areas of interest. The journal also includes selected readings and other essential references to encourage further in-depth exploration of specific topics.