Immunoglobulin A vasculitis with periorbital edema and severe renal involvement: A case report.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-21 DOI:10.1111/pde.15726

Le Wen Chiu, Basema I Dibas, Patrick D Walker, Aimee C Smidt, Nikifor K Konstantinov

引用次数: 0

Abstract

Immunoglobulin A (IgA) vasculitis, or Henoch-Schonlein purpura, is the most common systemic vasculitis in children, clinically presenting as palpable purpura in combination with arthritis, gastrointestinal involvement, or kidney injury. Subcutaneous edema is reported in patients with IgA vasculitis, and it commonly affects the lower extremities, especially around joints. Here, we report a case of IgA vasculitis with a rare presentation of edema isolated to the periorbital area in a 7-year-old boy, who subsequently developed crescentic glomerulonephritis with nephrotic range proteinuria. Isolated periorbital edema is an uncommon cutaneous feature of IgA vasculitis.

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免疫球蛋白 A 血管炎伴眶周水肿和严重肾脏受累：病例报告。

免疫球蛋白 A（IgA）血管炎或过敏性紫癜（Henoch-Schonlein purpura）是儿童最常见的全身性血管炎，临床表现为可触及的紫癜，同时伴有关节炎、胃肠道受累或肾损伤。有报告称，IgA 血管炎患者会出现皮下水肿，通常会影响下肢，尤其是关节周围。在此，我们报告了一例 IgA 血管炎病例，该病例罕见地表现为眶周孤立性水肿，患者为 7 岁男孩，随后发展为新月体肾小球肾炎，并伴有肾病范围蛋白尿。孤立性眶周水肿是 IgA 血管炎不常见的皮肤特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.