Conductive Hearing Loss Associates With Dementia, and Middle Ear Reconstruction Mitigates This Association: A Multinational Database Study.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-01 Epub Date: 2024-08-21 DOI:10.1097/MAO.0000000000004308

Zachary D Urdang, Amiti Jain, Marwin Li, Thomas L Haupt, Thomas O Wilcox, Rebecca C Chiffer, Richard K Gurgel

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Abstract

Objective: To test the hypothesis that conductive hearing loss (CHL) is associated with dementia, and that middle ear reconstruction (MER) associates with improved outcomes for these measures in a multinational electronic health records database.

Study design: Retrospective cohort study with propensity-score matching (PSM).

Setting: TriNetX is a research database representing about 110 million patients from the United States, Taiwan, Brazil, and India.

Patients: Subjects older than 50 years with no HL and any CHL (ICD-10: H90.0-2). Subjects of any age with and without any MER (CPT: 1010174).

Main outcome measures: Odds ratios (ORs) and hazard ratios with 95% confidence intervals (95% CIs) for incident dementia (ICD-10: F01, F03, G30).

Results: Of 103,609 patients older than 50 years experiencing any CHL, 2.74% developed dementia compared with 1.22% of 38,216,019 patients with no HL (OR, 95% CI: 2.29, 2.20-2.37). Of patients experiencing CHL, there were 39,850 who received MER. The average age was 31.3 years, with 51% female patients. A total of 343,876 control patients with CHL were identified; 39,900 patients remained in each cohort after 1:1 PSM for HL- and dementia-related risk factors. Matched risk for developing dementia among MER recipients was 0.33% compared with 0.58% in controls (OR: 0.58, 0.46-0.72).

Conclusions: CHL increases the odds for dementia, and MER improves the odds for incident dementia. This study represents the first population study on the topic of CHL, MER, and dementia.

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传导性听力损失与痴呆症有关，而中耳重建缓解了这种关联：一项跨国数据库研究

研究目的在跨国电子健康记录数据库中检验传导性听力损失（CHL）与痴呆症相关，以及中耳重建（MER）与改善这些指标的结果相关的假设：研究设计：采用倾向分数匹配（PSM）的回顾性队列研究：TriNetX是一个研究数据库，代表了来自美国、台湾、巴西和印度的约1.1亿名患者：50岁以上无HL和任何CHL（ICD-10：H90.0-2）的受试者。主要结果测量指标：主要结果测量：痴呆症（ICD-10：F01、F03、G30）发病率（ORs）和危险比（95% CIs）：在 103,609 名 50 岁以上患有任何慢性淋巴细胞白血病的患者中，2.74% 的人患上了痴呆症，而在 38,216,019 名未患有慢性淋巴细胞白血病的患者中，1.22% 的人患上了痴呆症（OR，95% CI：2.29，2.20-2.37）。在患有慢性淋巴细胞白血病的患者中，有 39 850 人接受了 MER 治疗。平均年龄为 31.3 岁，女性患者占 51%。共确定了 343,876 名患有慢性淋巴细胞白血病的对照组患者；在对与慢性淋巴细胞白血病和痴呆症相关的风险因素进行 1:1 PSM 后，每个队列中仍有 39,900 名患者。MER接受者患痴呆症的匹配风险为0.33%，而对照组为0.58%（OR：0.58，0.46-0.72）：结论：CHL会增加痴呆症的发病几率，而MER会提高痴呆症的发病几率。本研究是第一项以CHL、MER和痴呆症为主题的人群研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.