Central Retinal Thickness Variability as a Predictive Factor for Visual Acuity After Dexamethasone Implant in Retinal Vein Occlusion.

IF 0.9 4区医学 Q4 OPHTHALMOLOGY

Ophthalmic surgery, lasers & imaging retina Pub Date : 2024-12-01 Epub Date: 2024-08-01 DOI:10.3928/23258160-20240621-04

Sarunas P Daugirdas, Christopher M Maatouk, Hongxin J Lai, Miller J Ogidigben, Rishi P Singh

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Abstract

Background and objective: Investigate central retinal thickness (CRT) variability and changes in best-corrected visual acuity (BCVA) after 12 months in patients with retinal vein occlusion (RVO) treated with dexamethasone intravitreal implants.

Patients and methods: Post hoc analyses of two randomized trials in patients with macular edema associated with branch or central RVO treated with a 0.7-mg dexamethasone implant. Central retinal thickness standard deviation (CRT-SD) and central retinal thickness amplitude (CRT-A) were measures of variability. Analyses included multinomial and simple linear regression.

Results: In 400 patients, CRT-SD and CRT-A were significantly associated with central RVO, second dexamethasone implant, and baseline CRT. Baseline BCVA was associated with CRT-A. CRT-SD and CRT-A were significantly correlated with a 12-month change in BCVA (effect sizes of -0.032 and -0.013 letters/µm; P < 0.001). Patients in the highest CRT-SD quartile gained significantly fewer letters (+1.88 letters; 95% CI: -0.46 to 4.23).

Conclusion: Greater CRT variability was associated with smaller BCVA improvements in patients with RVO treated with dexamethasone implants. [Ophthalmic Surg Lasers Imaging Retina 2024;55:722-729.].

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视网膜静脉闭塞患者植入地塞米松后视网膜中央厚度变异性作为视力的预测因素

背景和目的：研究视网膜静脉闭塞（RVO）患者接受地塞米松玻璃体内植入治疗 12 个月后视网膜中央厚度（CRT）的变化和最佳矫正视力（BCVA）的变化：对两项随机试验进行事后分析，试验对象是接受 0.7 毫克地塞米松植入剂治疗的黄斑水肿伴有分支型或中心型 RVO 的患者。视网膜中央厚度标准偏差（CRT-SD）和视网膜中央厚度振幅（CRT-A）是衡量变异性的指标。分析包括多项式和简单线性回归：在 400 名患者中，CRT-SD 和 CRT-A 与中心 RVO、第二次地塞米松植入和基线 CRT 显著相关。基线 BCVA 与 CRT-A 相关。CRT-SD 和 CRT-A 与 BCVA 12 个月的变化有明显相关性（效应大小分别为 -0.032 和 -0.013 letters/µm；P < 0.001）。CRT-SD最高四分位数的患者获得的视力增益明显较少（+1.88个视力增益；95% CI：-0.46至4.23）：结论：在接受地塞米松植入治疗的 RVO 患者中，CRT 变异性越大，BCVA 改善越小。[眼科手术激光成像视网膜2024;55:XX-XX]。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmic surgery, lasers & imaging retina OPHTHALMOLOGY-SURGERY

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： OSLI Retina focuses exclusively on retinal diseases, surgery and pharmacotherapy. OSLI Retina will offer an expedited submission to publication effort of peer-reviewed clinical science and case report articles. The front of the journal offers practical clinical and practice management features and columns specific to retina specialists. In sum, readers will find important peer-reviewed retina articles and the latest findings in techniques and science, as well as informative business and practice management features in one journal.