Effect of Radiotherapy on the Adhesive Interface of Caries-affected Dentin and Bioactive Restorations: A Micro-CT Analysis.

IF 1.4 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Operative dentistry Pub Date : 2024-09-01 DOI:10.2341/23-128-L

L K Köse, B Oglakci, Z C Özduman, K Akdur, A Mayadağlı, N Arhun

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引用次数: 0

Abstract

Purpose: This study aimed to analyze the presence of defects within the adhesive interface formed with five bioactive dental materials and caries-affected dentin concerning the timing of radiotherapy (before or after the restorative procedures) by micro-CT.

Methods and materials: A total of 96 carious human molars were randomly allocated into the following groups based on the timing of the radiotherapy sequence: radiotherapy followed by restoration (RT1) or restoration followed by radiotherapy (RT2). Then, six subgroups were established within these groups based on the type of materials used (n=8). Following cavity preparation and caries removal, a universal adhesive (G-Premio Bond) was administered in self-etch mode or accompanied by applying suitable cavity conditioners according to the manufacturers' guidelines. Subsequently, restorations were performed using five bioactive restorative materials (resin-modified glass-ionomer [Fuji II LC], high-viscosity glass-ionomer hybrid [EQUIA Forte HT], giomer [Beautifil II], alkasite [Cention N], and dual-cure bulk-fill composite [Activa Bioactive Restorative]) and a conventional microhybrid resin composite (Filtek Z250). The radiotherapy regimen encompassed 60 Grays (Gy) administered at a rate of 2 Gy/day over 6 weeks, 5 days a week. Micro-CT analysis was employed to assess adhesive defects at the interface between caries-affected dentin and the restorations. The data were analyzed using Kruskal-Wallis, Mann-Whitney U, and Dunn tests (α=0.05).

Results: RT2 caused significantly higher adhesive defects than RT1 for the Filtek Z250 and Activa Bioactive Restorative subgroups (p<0.05). For RT1, no significant differences were found in adhesive defects among all tested subgroups (p>0.05). By contrast, for RT2, adhesive defects were significantly higher for the Activa Bioactive Restorative and Cention N subgroups than for the EQUIA Forte HT and Beautifil II subgroups (p<0.05).

Conclusions: When using most bioactive restorative materials, the timing of radiotherapy had no significant influence on the adhesive interface. Regarding restoration following a radiotherapy protocol, a favorable impact was identified with high-viscosity glass ionomer hybrid cement and giomer bioactive restorations compared with dual-cure bioactive bulk-fill composite and alkasite restorations.

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放疗对受龋齿影响的牙本质和生物活性修复体粘接界面的影响：显微 CT 分析。

目的：本研究旨在通过显微 CT 分析五种生物活性牙科材料与受龋病影响的牙本质形成的粘接界面内是否存在与放疗时间（修复程序之前或之后）有关的缺陷：根据放射治疗的时间顺序，将 96 颗龋坏的人类磨牙随机分为以下几组：先放射治疗后修复（RT1）或先修复后放射治疗（RT2）。然后，根据所使用材料的类型在这些组中设立了六个亚组（n=8）。在制备牙洞和去除龋齿后，根据制造商的指导，以自酸蚀模式使用通用粘合剂（G-Premio Bond），或同时使用适当的牙洞调节剂。随后，使用五种生物活性修复材料（树脂改性玻璃-离子体[Fuji II LC]、高粘度玻璃-离子体混合体[EQUIA Forte HT]、giomer[Beautifil II]、alkasite[Cention N]和双固化体填充复合材料[Activa 生物活性修复体]）和传统的微混合树脂复合材料（Filtek Z250）进行修复。放疗方案包括 60 格瑞（Gy），每天 2 Gy，持续 6 周，每周 5 天。采用显微 CT 分析评估受龋齿影响的牙本质与修复体之间界面的粘接缺陷。数据采用 Kruskal-Wallis、Mann-Whitney U 和 Dunn 检验进行分析（α=0.05）：结果：对于 Filtek Z250 和 Activa 生物活性修复体亚组，RT2 造成的粘接缺陷明显高于 RT1（P0.05）。相比之下，对于 RT2，Activa 生物活性修复体和 Cention N 亚组的粘接缺陷明显高于 EQUIA Forte HT 和 Beautifil II 亚组（P结论：在使用大多数生物活性修复材料时，放疗时间对粘接界面没有明显影响。关于放射治疗后的修复，与双固化生物活性膨体填充复合材料和烷基石修复体相比，高粘度玻璃离子聚合物混合粘结剂和giomer生物活性修复体具有有利的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Operative dentistry 医学-牙科与口腔外科

CiteScore

4.00

自引率

9.10%

发文量

124

审稿时长

6-12 weeks

期刊介绍： Operative Dentistry is a refereed, international journal published bi-monthly and distributed to subscribers in over 50 countries. In 2012, we printed 84 articles (672 pages). Papers were submitted by authors from 45 countries, in the categories of Clinical Research, Laboratory Research, Clinical Techniques/Case Presentations and Invited Papers, as well as Editorials and Abstracts. One of the strong points of our journal is that our current publication time for accepted manuscripts is 4 to 6 months from the date of submission. Clinical Techniques/Case Presentations have a very quick turnaround time, which allows for very rapid publication of clinical based concepts. We also provide color for those papers that would benefit from its use. The journal does not accept any advertising but you will find postings for faculty positions. Additionally, the journal also does not rent, sell or otherwise allow its subscriber list to be used by any other entity