Second Derivative of the Finger Photoplethysmogram Predicts the Risk of Developing Hypertension in Middle-Aged Men.

IF 3 2区 医学 Q2 PERIPHERAL VASCULAR DISEASE
Toshiaki Otsuka, Yasuhiro Nishiyama, Katsuhito Kato, Eitaro Kodani, Tomoyuki Kawada
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Abstract

Aim: Increased arterial stiffness impairs the functional and structural properties of arteries, which in turn elevates blood pressure (BP). The aim of this study was to test whether indices obtained from the second derivative of the finger photoplethysmogram (SDPTG), a marker of arterial stiffness, predict future development of hypertension in middle-aged men.

Methods: The SDPTG was measured in 902 men without hypertension (mean age 44±6 years) at an annual medical checkup. The development of hypertension was monitored for a maximum of 4 years. Two indices of arterial stiffness were calculated from the SDPTG waveforms: b/a, an index of large elastic arterial stiffness, and d/a, an index of systemic arterial stiffness, including the structural and functional properties of small and muscular arteries and peripheral circulation. A Cox proportional hazards model was used to examine whether the b/a and d/a ratios were independent predictors of future development of hypertension.

Results: During the follow-up period, 124 individuals developed hypertension, defined as a systolic/diastolic BP ≥ 140/90 mm Hg or the use of antihypertensive medications. The hazard ratio for the development of hypertension significantly increased in the lowest quartile of the d/a ratio (2.84, 95% confidence interval: 1.58-5.13, p<0.001) compared with the highest quartile, after adjusting for multiple potential confounders. In contrast, the b/a ratio did not show significant hazard ratios for the development of hypertension.

Conclusions: The d/a ratio, calculated from the SDPTG waveforms, predicted the risk of future development of hypertension in this study population.

手指光速图二次导数可预测中年男性患高血压的风险
目的:动脉僵化增加会损害动脉的功能和结构特性,进而导致血压(BP)升高。本研究的目的是测试作为动脉僵化标志的手指光速图二次导数(SDPTG)所获得的指数是否能预测中年男性高血压的未来发展:方法:对 902 名无高血压的男性(平均年龄为 44±6 岁)进行年度体检时的 SDPTG 测量。对高血压的发展进行了最长 4 年的监测。根据 SDPTG 波形计算出两个动脉僵化指数:b/a 是大弹性动脉僵化指数,d/a 是全身动脉僵化指数,包括小动脉、肌肉动脉和外周循环的结构和功能特性。采用 Cox 比例危险模型来检验 b/a 和 d/a 比率是否是未来高血压发病的独立预测因素:结果:在随访期间,124 人患上了高血压,即收缩压/舒张压≥ 140/90 mm Hg 或服用降压药。在调整了多种潜在的混杂因素后,与最高四分位数相比,d/a 比值最低的四分位数发生高血压的危险比显著增加(2.84,95% 置信区间:1.58-5.13,p<0.001)。相比之下,b/a 比值对高血压发病的危险比并不显著:结论:根据 SDPTG 波形计算出的 d/a 比值可预测该研究人群未来罹患高血压的风险。
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来源期刊
CiteScore
6.60
自引率
15.90%
发文量
271
审稿时长
1 months
期刊介绍: JAT publishes articles focused on all aspects of research on atherosclerosis, vascular biology, thrombosis, lipid and metabolism.
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