Tofacitinib in the Management of Alopecia Universalis.

Q2 Medicine
International Journal of Trichology Pub Date : 2023-09-01 Epub Date: 2024-07-11 DOI:10.4103/ijt.ijt_77_23
Prashant Agarwal
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引用次数: 0

Abstract

Alopecia universalis (AU) is a rare form of hair loss characterized by the complete absence of hair on the scalp and body. It is an advanced form of alopecia areata. There is currently no definitive treatment for this condition, and management options are limited. This case report describes the successful treatment of a 37-year-old female patient with AU using oral tofacitinib 5 mg BID, an oral Janus kinase inhibitor. The patient experienced clinically significant hair regrowth on the scalp and eyebrows after 6 months of treatment with tofacitinib, along with the concurrent use of oral mini-pulse betamethasone, topical minoxidil 5%, and clobetasol lotion. This case highlights the potential efficacy of tofacitinib as a promising therapeutic option for AU, without notable safety concerns. Moreover, it is also well tolerated in this patient.

托法替尼治疗斑秃
普遍性脱发(AU)是一种罕见的脱发,其特征是头皮和身体上完全没有头发。它是斑秃的一种晚期形式。目前尚无确切的治疗方法,治疗方案也很有限。本病例报告介绍了使用口服 Janus 激酶抑制剂托法替尼(tofacitinib)5 毫克,每日两次成功治疗一名 37 岁女性斑秃患者的情况。在使用托法替尼治疗 6 个月后,患者的头皮和眉毛出现了明显的毛发再生,同时还使用了口服小脉冲倍他米松、5% 米诺地尔外用药和氯倍他索洗剂。本病例突出了托法替尼作为治疗非淋菌性尿道炎的一种有前途的治疗方案的潜在疗效,而且没有明显的安全性问题。此外,该患者对该药物的耐受性也很好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.50
自引率
0.00%
发文量
38
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