Oral Risk Factors in Patients with Cancer Undergoing Chemotherapy - A Pilot Study.

Q3 Dentistry
Indian Journal of Dental Research Pub Date : 2024-04-01 Epub Date: 2024-08-22 DOI:10.4103/ijdr.ijdr_516_23
Anupama Aradya, P K Kiran, K N Raghavendra Swamy, Vidya G Doddawad, Narahari Ranganatha, Koduru Sravani
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引用次数: 0

Abstract

Background: Treatment modalities for cancer including surgery, radiotherapy and chemotherapy, have some complications even in the oral cavity. The literature describes oral lesions that may arise as a result of chemotherapy. However, information regarding oral symptoms in advanced cancer patients is poor.

Objective: To identify the oral manifestations like oral mucositis, dry mouth and loss of taste in patients undergoing chemotherapy treatment.

Methods: We evaluated 60 patients affected by malignancy undergoing chemotherapy treatment. The clinical and pathological data such as age, gender, diagnosis of malignancy and types of treatments with anticancer chemotherapeutic drug treatment, were obtained. Patients were routinely evaluated for the presence of oral mucositis based on the Common Terminology Criteria for Adverse Events (CTCAE) v5.0 scale for adverse effects and graded. Other findings like dry mouth and loss of taste were recorded.

Results: Of the 60 patients, 40 (66.6%) were male, and 20 (33.3%) females with a mean age of 53.7 years. Most patients about 63% and 83% were diagnosed with dry mouth and loss of taste, respectively and 71% of patients had mucositis. Chemotherapy drugs like Cyclophosphamide, carboplatin, nanoxel, paclitaxel, oxaliplatin, docetaxel and doxorubicin, were directly associated with oral mucositis.

Conclusion: Patients treated with chemotherapy for cancer most often suffer from a multitude of intense and debilitating oral dysfunctions. Oral lesions found in patients undergoing chemotherapy were mucositis, dry mouth and loss of taste. These adverse effects and an appropriate symptomatic therapy need to be discussed with the patients. Chemotherapy has a significant but transient effect on the oral symptoms.

接受化疗的癌症患者的口腔风险因素--一项试点研究。
背景:癌症的治疗方法包括手术、放疗和化疗,即使在口腔中也会出现一些并发症。文献描述了化疗可能导致的口腔病变。然而,有关晚期癌症患者口腔症状的资料却很少:目的:确定化疗患者的口腔表现,如口腔黏膜炎、口干和味觉丧失:我们对 60 名接受化疗的恶性肿瘤患者进行了评估。方法:我们对 60 名接受化疗的恶性肿瘤患者进行了评估,获得了他们的临床和病理数据,如年龄、性别、恶性肿瘤诊断和抗癌化疗药物治疗类型。根据不良反应通用术语标准(CTCAE)v5.0,对患者是否出现口腔黏膜炎进行常规评估和分级。此外,还记录了口干和味觉丧失等其他发现:在 60 名患者中,男性 40 名(66.6%),女性 20 名(33.3%),平均年龄 53.7 岁。大多数患者(约 63% 和 83%)被诊断为口干和味觉丧失,71% 的患者患有粘膜炎。环磷酰胺、卡铂、纳铂、紫杉醇、奥沙利铂、多西他赛和多柔比星等化疗药物与口腔黏膜炎直接相关:结论:接受化疗的癌症患者通常会出现多种严重的口腔功能障碍。化疗患者的口腔病变包括粘膜炎、口干和味觉丧失。需要与患者讨论这些不良反应和适当的对症疗法。化疗对口腔症状有明显但短暂的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Indian Journal of Dental Research
Indian Journal of Dental Research Dentistry-Dentistry (all)
CiteScore
1.80
自引率
0.00%
发文量
80
审稿时长
38 weeks
期刊介绍: Indian Journal of Dental Research (IJDR) is the official publication of the Indian Society for Dental Research (ISDR), India section of the International Association for Dental Research (IADR), published quarterly. IJDR publishes scientific papers on well designed and controlled original research involving orodental sciences. Papers may also include reports on unusual and interesting case presentations and invited review papers on significant topics.
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