A Quantitative Assessment of Apoptotic Index with Varying Histological Degree of Dysplasia and Squamous Cell Carcinoma of Oral Cavity - A Light Microscopic Study.

Q3 Dentistry
Indian Journal of Dental Research Pub Date : 2024-04-01 Epub Date: 2024-08-22 DOI:10.4103/ijdr.ijdr_382_23
Chitrapriya Saxena, Vijay Wadhwan, Vijay Kumar, Aparna Singh, Siddharth Anand, Asib Ahmad
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引用次数: 0

Abstract

Aim and objective: The aim of the present study was to quantitatively assess the apoptotic index at a light microscopic level in hyperkeratosis with varying histological degrees of dysplasia and different grades of oral squamous cell carcinoma (OSCC) and its correlation with prognostic significance.

Study design: The study included the histo-pathologically diagnosed cases of hyperkeratosis with varying degrees of dysplasia and different grades of OSCC, which were retrieved from the archives of the department, and clinical details were retrieved from the case records of the patients. The sample size consisted of 80 biopsied cases, divided into seven groups of 10 experimental cases and one group of 10 cases of normal mucosa as a control group.

Results: The age range of 50-59 shows maximum patients of hyperkeratosis with varying degrees of dysplasia and OSCC. Maximum apoptotic bodies were seen in cases of severe dysplasia and well-differentiated cases of OSCC. There was an observational difference noticed in apoptotic bodies between the patients who had less than 1-year disease-free survival rate.

Conclusions: The apoptotic cells are being seen using routine light microscopy techniques with hematoxylin and eosin staining. In different grades of squamous cell carcinoma, a decrease in the apoptotic count was noticed from well-differentiated squamous cell carcinoma toward poorly differentiated squamous cell carcinoma cases. Increased mean apoptotic bodies were observed in patients showing less than 1 year of survival.

不同组织学程度的口腔增生异常和鳞状细胞癌凋亡指数的定量评估--一项光学显微镜研究。
目的和目标本研究的目的是在光镜下定量评估不同组织学发育不良程度的角化过度和不同等级的口腔鳞状细胞癌(OSCC)的细胞凋亡指数及其与预后的相关性:研究对象包括经病理组织学诊断为不同程度发育不良的过度角化症和不同等级的口腔鳞状细胞癌(OSCC)病例。样本量包括 80 例活检病例,分为 7 组,每组 10 例实验病例,1 组 10 例正常黏膜病例作为对照组:结果:年龄在 50-59 岁之间的角化过度患者最多,同时伴有不同程度的发育不良和 OSCC。严重发育不良和分化良好的 OSCC 病例中凋亡体最多。观察发现,无病生存率低于1年的患者的凋亡体存在差异:结论:使用苏木精和伊红染色的常规光学显微镜技术可观察到凋亡细胞。在不同等级的鳞状细胞癌中,凋亡细胞数从分化良好的鳞状细胞癌向分化不良的鳞状细胞癌病例减少。在存活期不足一年的患者中,平均凋亡体增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Indian Journal of Dental Research
Indian Journal of Dental Research Dentistry-Dentistry (all)
CiteScore
1.80
自引率
0.00%
发文量
80
审稿时长
38 weeks
期刊介绍: Indian Journal of Dental Research (IJDR) is the official publication of the Indian Society for Dental Research (ISDR), India section of the International Association for Dental Research (IADR), published quarterly. IJDR publishes scientific papers on well designed and controlled original research involving orodental sciences. Papers may also include reports on unusual and interesting case presentations and invited review papers on significant topics.
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