Application of decalcified bone matrix in Salmon bone for tibial defect repair in rat model.

IF 1.4 4区医学 Q4 ENGINEERING, BIOMEDICAL

International Journal of Artificial Organs Pub Date : 2024-10-01 Epub Date: 2024-08-22 DOI:10.1177/03913988241269498

Tong Wu, Lei Han, Ye Zhu, Xiaojun Zeng, Yating Kang, Shuwen Zheng, Zhenhai Wang, Jianping Wang, Yonglin Gao

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引用次数: 0

Abstract

Aim: The optimal preparation conditions of Salmon decalcified bone matrix (S-DBM) were explored, and the properties of S-DBM bone particles and bone powder were studied respectively. The therapeutic effect of S-DBM on tibial defect in female Sprague Dawley (SD) rats was preliminarily verified.

Methods: This study assessed the structural and functional similarities of Salmon bone DBM (S-DBM). The biocompatibility assessment was conducted using both in vivo and in vitro experiments, establishing an animal model featuring tibial defects in rats and on the L929 cell line, respectively. The control group, bovine DBM (bDBM), was compared to the S-DBM-treated tibial defect rats. Imaging and histology were used to study implant material changes, defect healing, osteoinductive repair, and degradation.

Results: The findings of our study indicate that S-DBM exhibits favorable repairing effects on bone defects, along with desirable physicochemical characteristics, safety, and osteogenic activity.

Conclusions: The S-DBM holds significant potential as a medical biomaterial for treating bone defects, effectively fulfilling the clinical demands for materials used in bone tissue repair engineering.

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在大鼠模型中应用鲑鱼骨脱钙骨基质修复胫骨缺损。

目的：探讨鲑鱼脱钙骨基质（Salmon decalcified bone matrix，S-DBM）的最佳制备条件，并分别研究S-DBM骨颗粒和骨粉的特性。初步验证了 S-DBM 对雌性 Sprague Dawley（SD）大鼠胫骨缺损的治疗效果：本研究评估了鲑鱼骨 DBM（S-DBM）的结构和功能相似性。生物相容性评估是通过体内和体外实验进行的，分别建立了以大鼠胫骨缺损和 L929 细胞系为特征的动物模型。对照组牛 DBM（bDBM）与经 S-DBM 处理的胫骨缺损大鼠进行了比较。通过成像和组织学研究了植入材料的变化、缺损愈合、骨诱导修复和降解：我们的研究结果表明，S-DBM 对骨缺损具有良好的修复效果，同时还具有理想的理化特性、安全性和成骨活性：结论：S-DBM 作为一种治疗骨缺损的医用生物材料具有巨大潜力，可有效满足骨组织修复工程对材料的临床需求。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Artificial Organs 医学-工程：生物医学

CiteScore

3.40

自引率

5.90%

发文量

审稿时长

3 months

期刊介绍： The International Journal of Artificial Organs (IJAO) publishes peer-reviewed research and clinical, experimental and theoretical, contributions to the field of artificial, bioartificial and tissue-engineered organs. The mission of the IJAO is to foster the development and optimization of artificial, bioartificial and tissue-engineered organs, for implantation or use in procedures, to treat functional deficits of all human tissues and organs.