Leukotriene signaling in neurodegeneration: implications for treatment strategies.

IF 4.6 2区 医学 Q2 IMMUNOLOGY
Inflammopharmacology Pub Date : 2024-12-01 Epub Date: 2024-08-21 DOI:10.1007/s10787-024-01557-1
Veerta Sharma, Prateek Sharma, Thakur Gurjeet Singh
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引用次数: 0

Abstract

Leukotrienes (LTs) are a group of substances that cause inflammation. They are produced by the enzyme 5-lipoxygenase (5-LOX) from arachidonic acid. Cysteinyl LTs are a group of lipid molecules that have a prominent role in inflammatory signaling in the allergic diseases. Although they are traditionally known for their role in allergic disease, current advancements in bio-medical research have shed light on the involvement of these inflammatory mediators in diseases such as in the inflammation related to central nervous system (CNS) disorders. Among the CNS diseases, LTs, along with 5-LOX and their receptors, have been shown to be associated with multiple sclerosis (MS), Alzheimer's disease (AD), and Parkinson's disease (PD). Through a comprehensive review of current research and experimentation, this investigation provides an insight on the biosynthesis, receptors, and biological effects of LTs in the body. Furthermore, implications of leukotriene signaling in CNS and its intricate role in neurodegeneration are also studied. Through the revelation of these insights, our aim is to establish a foundation for the development of enhanced and focused therapeutic approaches in the continuous endeavor to combat neurodegeneration. Furthermore, the pharmacological inhibition of leukotriene signaling with selective inhibitors offers promising prospects for future interventions and treatments for neurodegenerative diseases.

Abstract Image

神经退行性变中的白三烯信号转导:对治疗策略的影响。
白三烯(LTs)是一组导致炎症的物质。它们由花生四烯酸的 5-脂氧合酶(5-LOX)产生。Cysteinyl LTs 是一类脂质分子,在过敏性疾病的炎症信号转导中发挥着重要作用。尽管传统上人们都知道它们在过敏性疾病中的作用,但目前生物医学研究的进展已经揭示了这些炎症介质在疾病中的参与,例如在与中枢神经系统(CNS)疾病相关的炎症中的参与。在中枢神经系统疾病中,LTs、5-LOX 及其受体已被证明与多发性硬化症(MS)、阿尔茨海默病(AD)和帕金森病(PD)有关。本研究通过对当前研究和实验的全面回顾,深入探讨了白三烯在体内的生物合成、受体和生物效应。此外,还研究了白三烯信号在中枢神经系统中的影响及其在神经退行性变中的复杂作用。我们的目标是通过揭示这些见解,为开发更强、更有针对性的治疗方法奠定基础,从而不断努力对抗神经退行性病变。此外,利用选择性抑制剂对白三烯信号转导进行药理抑制,为未来干预和治疗神经退行性疾病提供了广阔的前景。
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来源期刊
Inflammopharmacology
Inflammopharmacology IMMUNOLOGYTOXICOLOGY-TOXICOLOGY
CiteScore
8.00
自引率
3.40%
发文量
200
期刊介绍: Inflammopharmacology is the official publication of the Gastrointestinal Section of the International Union of Basic and Clinical Pharmacology (IUPHAR) and the Hungarian Experimental and Clinical Pharmacology Society (HECPS). Inflammopharmacology publishes papers on all aspects of inflammation and its pharmacological control emphasizing comparisons of (a) different inflammatory states, and (b) the actions, therapeutic efficacy and safety of drugs employed in the treatment of inflammatory conditions. The comparative aspects of the types of inflammatory conditions include gastrointestinal disease (e.g. ulcerative colitis, Crohn''s disease), parasitic diseases, toxicological manifestations of the effects of drugs and environmental agents, arthritic conditions, and inflammatory effects of injury or aging on skeletal muscle. The journal has seven main interest areas: -Drug-Disease Interactions - Conditional Pharmacology - i.e. where the condition (disease or stress state) influences the therapeutic response and side (adverse) effects from anti-inflammatory drugs. Mechanisms of drug-disease and drug disease interactions and the role of different stress states -Rheumatology - particular emphasis on methods of measurement of clinical response effects of new agents, adverse effects from anti-rheumatic drugs -Gastroenterology - with particular emphasis on animal and human models, mechanisms of mucosal inflammation and ulceration and effects of novel and established anti-ulcer, anti-inflammatory agents, or antiparasitic agents -Neuro-Inflammation and Pain - model systems, pharmacology of new analgesic agents and mechanisms of neuro-inflammation and pain -Novel drugs, natural products and nutraceuticals - and their effects on inflammatory processes, especially where there are indications of novel modes action compared with conventional drugs e.g. NSAIDs -Muscle-immune interactions during inflammation [...]
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