Lymphatic System Development and Function.

IF 3.1 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Cardiology Reports Pub Date : 2024-11-01 Epub Date: 2024-08-22 DOI:10.1007/s11886-024-02120-8

Harish P Janardhan, Brianna T Wachter, Chinmay M Trivedi

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引用次数: 0

Abstract

Purpose of review: This review delves into recent advancements in understanding generalized and organ-specific lymphatic development. It emphasizes the distinct characteristics and critical anomalies that can impair lymphatic function. By exploring developmental mechanisms, the review seeks to illuminate the profound impact of lymphatic malformations on overall health and disease progression.

Recent findings: The introduction of genome sequencing, single-cell transcriptomic analysis, and advanced imaging technologies has significantly enhanced our ability to identify and characterize developmental defects within the lymphatic system. As a result, a wide range of lymphatic anomalies have been uncovered, spanning from congenital abnormalities present at birth to conditions that can become life-threatening in adulthood. Additionally, recent research highlights the heterogeneity of lymphatics, revealing organ-specific developmental pathways, unique molecular markers, and specialized physiological functions specific to each organ. A deeper understanding of the unique characteristics of lymphatic cell populations in an organ-specific context is essential for guiding future research into lymphatic disease processes. An integrated approach to translational research could revolutionize personalized medicine, where treatments are precisely tailored to individual lymphatic profiles, enhancing effectiveness and minimizing side effects.

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淋巴系统的发育和功能

综述的目的：本综述深入探讨了了解全身和器官特异性淋巴发育的最新进展。它强调了可能损害淋巴功能的明显特征和关键异常。通过探讨发育机制，综述试图阐明淋巴畸形对整体健康和疾病进展的深远影响：基因组测序、单细胞转录组分析和先进成像技术的引入大大提高了我们识别和描述淋巴系统发育缺陷的能力。因此，我们发现了多种淋巴异常，从出生时的先天性异常到成年后可能危及生命的疾病。此外，最近的研究突出了淋巴管的异质性，揭示了器官特异性发育途径、独特的分子标记和每个器官特有的生理功能。深入了解淋巴细胞群在器官特异性背景下的独特特征，对于指导未来的淋巴疾病过程研究至关重要。转化研究的综合方法可彻底改变个性化医疗，根据淋巴特征精确定制治疗方案，提高疗效并减少副作用。

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来源期刊

Current Cardiology Reports CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

6.20

自引率

2.70%

发文量

209

期刊介绍： The aim of this journal is to provide timely perspectives from experts on current advances in cardiovascular medicine. We also seek to provide reviews that highlight the most important recently published papers selected from the wealth of available cardiovascular literature. We accomplish this aim by appointing key authorities in major subject areas across the discipline. Section editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. We also provide commentaries from well-known figures in the field.