SNORA5A regulates tumor-associated macrophage M1/M2 phenotypes via TRAF3IP3 in breast cancer.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-19 eCollection Date: 2024-01-01 DOI:10.1590/1414-431X2024e13809

Yiqi Zhang, Ang Zheng, Yue Shi, Heng Lu

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Abstract

Small nucleolar RNAs (snoRNAs) have robust potential functions and therapeutic value in breast cancer. Herein, we investigated the role SNORA5A in breast cancer. Samples from The Cancer Genome Atlas (TCGA) were reviewed. The transcription matrix and clinical information were analyzed using R software and validated in clinical tissue samples. SNORA5A was significantly down-regulated in breast cancer, and high expression of SNORA5A correlated with a favorable prognosis. High expression of SNORA5A induced a high concentration of tumor-associated macrophages M1 and a low concentration of tumor-associated macrophages M2. Moreover, SNORA5A were clustered in terms related to cancer and immune functions. Possible downstream molecules of SNORA5A were identified, among which TRAF3IP3 was positively correlated with M1 and negatively correlated with M2. The function of TRAF3IP3 in tumor inhibition and its relationship with macrophages in clinical tissue samples were in accordance with bioinformatics analysis results. SNORA5A could regulate macrophage phenotypes through TRAF3IP3 and serves as a potential prognostic marker for breast cancer patients.

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SNORA5A 通过 TRAF3IP3 调节乳腺癌中肿瘤相关巨噬细胞 M1/M2 的表型。

小核RNA（snoRNA）在乳腺癌中具有强大的潜在功能和治疗价值。在此，我们研究了 SNORA5A 在乳腺癌中的作用。我们查阅了癌症基因组图谱（TCGA）中的样本。利用 R 软件分析了转录矩阵和临床信息，并在临床组织样本中进行了验证。SNORA5A在乳腺癌中明显下调，SNORA5A的高表达与良好的预后相关。SNORA5A的高表达诱导了高浓度的肿瘤相关巨噬细胞M1和低浓度的肿瘤相关巨噬细胞M2。此外，SNORA5A与癌症和免疫功能相关。研究发现了 SNORA5A 的可能下游分子，其中 TRAF3IP3 与 M1 呈正相关，与 M2 呈负相关。TRAF3IP3在抑制肿瘤中的功能及其与临床组织样本中巨噬细胞的关系与生物信息学分析结果一致。SNORA5A可通过TRAF3IP3调控巨噬细胞表型，并可作为乳腺癌患者的潜在预后标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.