Copper Toxicity in Animals: A Review.

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biological Trace Element Research Pub Date : 2024-08-21 DOI:10.1007/s12011-024-04345-8

Yudong Wang, Qiushi Yan, Yang Shi, Miao Long

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Abstract

Copper is an essential trace element in animals and humans. However, excessive intake of copper can cause copper ions to accumulate in tissues and organs of animals, leading to copper toxicity. Copper ions induce apoptosis and autophagy through oxidative stress-mediated mitochondrial dysfunction. In addition, copper induces cell death by targeting lipoylated tricarboxylic acid (TCA) cycling proteins, termed cuproptosis. In recent years, copper cytotoxicity studies have attracted attention. In addition, the number of cases of copper toxicity in animals has been increasing over the past years due to environmental pollution and overdose from copper feed supplements. Therefore, a comprehensive understanding of copper toxicity and the metabolism of copper ions can aid in devising strategies for preventing copper toxicity. This review introduces the tissue and organ toxicity and cytotoxicity caused by copper toxicity and reviews the metabolism of copper ions in tissues, organs, and cells. The paper also reviews the clinical cases and animal experiments of copper toxicity in recent years. Finally, the preventive and curative measures for copper toxicity and the future challenges are also discussed. The general objective of this paper is to provide a reliable reference for copper toxicity prevention.

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动物体内的铜毒性：综述。

铜是动物和人类必需的微量元素。然而，过量摄入铜会导致铜离子在动物的组织和器官中蓄积，从而引起铜中毒。铜离子通过氧化应激介导的线粒体功能障碍诱导细胞凋亡和自噬。此外，铜还通过靶向脂酰化三羧酸（TCA）循环蛋白诱导细胞死亡，即所谓的铜中毒。近年来，铜细胞毒性研究备受关注。此外，由于环境污染和铜饲料添加剂的过量摄入，动物铜中毒的病例在过去几年中不断增加。因此，全面了解铜毒性和铜离子的新陈代谢有助于制定预防铜毒性的策略。本综述介绍了铜毒性引起的组织器官毒性和细胞毒性，并回顾了铜离子在组织、器官和细胞中的代谢。本文还回顾了近年来铜中毒的临床病例和动物实验。最后，还讨论了铜中毒的防治措施和未来的挑战。本文的总体目标是为铜中毒的预防提供可靠的参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biological Trace Element Research 生物-内分泌学与代谢

CiteScore

8.70

自引率

10.30%

发文量

459

审稿时长

2 months

期刊介绍： Biological Trace Element Research provides a much-needed central forum for the emergent, interdisciplinary field of research on the biological, environmental, and biomedical roles of trace elements. Rather than confine itself to biochemistry, the journal emphasizes the integrative aspects of trace metal research in all appropriate fields, publishing human and animal nutritional studies devoted to the fundamental chemistry and biochemistry at issue as well as to the elucidation of the relevant aspects of preventive medicine, epidemiology, clinical chemistry, agriculture, endocrinology, animal science, pharmacology, microbiology, toxicology, virology, marine biology, sensory physiology, developmental biology, and related fields.