The role of phagocytic cells in aging: insights from vertebrate and invertebrate models.

IF 4.4 4区 医学 Q1 GERIATRICS & GERONTOLOGY
Biogerontology Pub Date : 2024-11-01 Epub Date: 2024-08-21 DOI:10.1007/s10522-024-10131-9
Brecht Driesschaert, Lucas Mergan, Cristiano Lucci, Caroline Simon, Dulce Santos, Lies De Groef, Liesbet Temmerman
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引用次数: 0

Abstract

While the main role of phagocytic scavenger cells consists of the neutralization and elimination of pathogens, they also keep the body fluids clean by taking up and breaking down waste material. Since a build-up of waste is thought to contribute to the aging process, these cells become particularly pertinent in the research field of aging. Nevertheless, a direct link between their scavenging functions and the aging process has yet to be established. Integrative approaches involving various model organisms hold promise to elucidate this potential, but are lagging behind since the diversity and evolutionary relationship of these cells across animal species remain unclear. In this perspective, we review the current knowledge associating phagocytic scavenger cells with aging in vertebrate and invertebrate animals, as well as put forward important questions for further exploration. Additionally, we highlight future challenges and propose a constructive approach for tackling them.

Abstract Image

吞噬细胞在衰老中的作用:脊椎动物和无脊椎动物模型的启示。
虽然吞噬清除细胞的主要作用是中和并消除病原体,但它们也通过吸收和分解废物来保持体液清洁。由于废物的堆积被认为会导致衰老,因此这些细胞在衰老研究领域显得尤为重要。然而,这些细胞的清除功能与衰老过程之间的直接联系尚未确立。涉及各种模式生物的综合方法有望阐明这一潜力,但由于这些细胞在动物物种间的多样性和进化关系仍不清楚,因此这种方法还很落后。在这一视角中,我们回顾了脊椎动物和无脊椎动物中吞噬清扫细胞与衰老相关的现有知识,并提出了有待进一步探索的重要问题。此外,我们还强调了未来的挑战,并提出了应对这些挑战的建设性方法。
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来源期刊
Biogerontology
Biogerontology 医学-老年医学
CiteScore
8.00
自引率
4.40%
发文量
54
审稿时长
>12 weeks
期刊介绍: The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.
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