{"title":"Phenotype and specificity of lung T cell responses correlate with outcome in SARS-CoV-2 pneumonia","authors":"","doi":"10.1038/s41590-024-01941-7","DOIUrl":null,"url":null,"abstract":"Profiling of T cell responses in the lungs of patients with pneumonia revealed that early and persistent enrichment of T cells correlates with survival from SARS-CoV-2 pneumonia. Notably, lung T cells with an interferon-stimulated profile and specific for SARS-CoV-2 structural proteins support survival, whereas those that gain a nuclear factor-κB (NF-κB)-driven inflammatory profile and are directed against nonstructural proteins were associated with poor clinical outcomes.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":null,"pages":null},"PeriodicalIF":27.7000,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Immunology","FirstCategoryId":"3","ListUrlMain":"https://www.nature.com/articles/s41590-024-01941-7","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Profiling of T cell responses in the lungs of patients with pneumonia revealed that early and persistent enrichment of T cells correlates with survival from SARS-CoV-2 pneumonia. Notably, lung T cells with an interferon-stimulated profile and specific for SARS-CoV-2 structural proteins support survival, whereas those that gain a nuclear factor-κB (NF-κB)-driven inflammatory profile and are directed against nonstructural proteins were associated with poor clinical outcomes.
对肺炎患者肺部 T 细胞反应的分析表明,T 细胞的早期和持续富集与 SARS-CoV-2 肺炎患者的存活率相关。值得注意的是,具有干扰素刺激特征和针对 SARS-CoV-2 结构蛋白特异性的肺 T 细胞有助于存活,而那些获得核因子-κB (NF-κB) 驱动的炎症特征和针对非结构蛋白的肺 T 细胞则与不良的临床结果有关。
期刊介绍:
Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.