Front Cover: Rhein-based Pickering emulsion for hepatocellular carcinoma: Shaping the metabolic signaling and immunoactivation in transarterial chemoembolization
Xiaoliu Liang, Hui Liu, Hu Chen, Xuqi Peng, Zhenjie Li, Minglei Teng, Yisheng Peng, Jiwei Li, Linyu Ding, Jingsong Mao, Chengchao Chu, Hongwei Cheng, Gang Liu
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引用次数: 0
Abstract
This study identifies metabolic reprogramming and immunosuppression as key factors in transarterial chemoembolization (TACE) refractoriness. Rhein is optimized as a glycolytic inhibitor and immunoactivator to enhance tumor response to TACE. An oil-in-water lipiodol emulsion stabilized with Rhein nanogel holds enhanced mechanical stability, ensuring effective embolization, prolonged drug release, and potent anti-tumor immunity, presenting a new approach for TACE (e552).
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